Heterobicyclic compounds

1. A compound of Formula (I):

or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, wherein:

each p and q is independently 1; wherein the sum of p and q is 2;

m is 0, 1, 2, 3, or 4;

A is a 9- to 10-membered heterocyclic ring having the formula:

wherein the group —W-T-D< is selected from the group consisting of: —N═CR 5 —N<; NR 7 —N═C<; —NR 7 —(C═O)—N<; NR 7 —CR 6 R 7 —(C═O)—N<; —NR 7 —(SO 2 )—N<; —CR 5 ═CR 5 —N<; —CR 8 ═N—N<; —CR 6 R 7 —(C═O)—N<; —CR 6 R 7 —NR 7 —(C═O)—N<; —CR 6 R 7 —O—(C═O)—N<; —CR 6 R 7 —(SO 2 )—N<; —O—(C═O)—N<; and —O—CR 6 R 7 —(C═O)—N<;

J is CR 3c ; wherein each E, X, Y, and Z is independently N or CR 4 ; wherein 1, 2, or 3 of E, X, Y, and Z are N;

G is R 1 , —NR 1 R 2 ; —NH(C═O)R 1 ; —OR 1 , —(C═O)R 1 ; or —CHR 1 R 2 ;

R 1 is a carbon-linked or nitrogen-linked saturated, partially-saturated or unsaturated 9- or 10-membered bicyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 1 is independently substituted by 0, 1, 2 or 3 R 9 groups;

R 2 is independently H, OH, C 1-4 alk, a carbon-linked or nitrogen-linked saturated, partially-saturated, or unsaturated 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 2 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

each R 3a and R 3c is independently H, F, OH, C 1-4 alk, or C 1-4 haloalk;

R 3b is independently F, Cl, Br, CN, OH, OC 1-4 alk, C 1-4 alk, C 1-4 haloalk, or oxo;

R 4 is halo, R 4a , —SR 4a , —OR 4a , —NHR 4a , or —N(C 1-4 alk)R 4a , wherein —R 4a is H, C 1-4 alk, a saturated, partially-saturated or unsaturated 3-, 4-, 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 4 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

each R 5 is independently R 5a , —OR 5b , —NHR 5a , or —N(C 1-4 alk)R 5a , wherein R 5a is H or C 1-4 alk; R 5b is C 1-4 alk, a saturated, partially-saturated or unsaturated 3-, 4-, 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 5 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

each R 6 and R 7 is independently H, halo, OH, C 1-4 alk, OC 1-4 alk, a saturated, partially-saturated or unsaturated 3-, 4-, 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 6 and R 7 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

or R 6 and R 7 may optionally form a saturated or partially-saturated 3-, 4-, 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein said monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

R 8 is R 8a , —O—R 8a , —NHR 8a , or —N(C 1-4 alk)R 8a , wherein R 8a is H, C 1-4 alk, a saturated, partially-saturated or unsaturated 3-, 4-, 5- or 6-membered monocyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 8 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups;

R 9 is independently F, Cl, Br, C 1-6 alk, C 1-4 haloalk, —OR a , OR c , —OC 1-4 haloalk, CN, —C(═O)R b , —C(═O)R c , —C(═O)OR a , —C(═O)NR a R a , —C(═O)NR a R c , —C(═NR a )NR a R a , —OC(═O)R b , —OC(═O)NR a R a , —OC 1-6 alkNR a R a , —OC 1-6 alkOR a , —SR a , —S(═O)R b , —S(═O) 2 R b , —S(═O) 2 NR a R a , —NR a R a , —N(R a )C(═O)R b , —N(R a )C(═O)OR b , —N(R a )C(═O)NR a R a , —N(R a )C(═NR a )NR a R a , —N(R a )S(═O) 2 R b , —N(R a )S(═O) 2 NR a R a , —NR a C 1-6 alkNR a R a , —NR a C 1-6 alkOR a , —C 1-6 alkNR a R a , —C 1-6 alkOR a , —C 1-6 alkN(R a )C(═O)R b , —C 1-6 alkOC(═O)R b , —C 1-6 alkC(═O)NR a R a , —C 1-6 alkC(═O)OR a , or oxo;

R 10 is halo, C 1-6 alk, C 1-4 haloalk, —OR a , —OC 1-4 haloalk, CN, —C(═O)R b , —C(═O)OR a , —C(═O)NR a R a , —C(═NR a )NR a R a , —OC(═O)R b , —OC(═O)NR a R a , —OC 1-6 alkNR a R a , —OC 1-6 alkOR a , —SR a , —S(═O)R b , —S(═O) 2 R b , —S(═O) 2 NR a R a , —NR a R a , —N(R a )C(═O)R b , —N(R a )C(═O)OR b , —N(R a )C(═O)NR a R a , —N(R a )C(═NR a )NR a R a , —N(R a )S(═O) 2 R b , —N(R a )S(═O) 2 NR a R a , —NR a C 1-6 alkNR a R a , —NR a C 1-6 alkOR a , —C 1-6 alkNR a R a , —C 1-6 alkOR a , —C 1-6 alkN(R a )C(═O)R b , —C 1-6 alkOC(═O)R b , —C 1-6 alkC(═O))NR a R a , —C 1-6 alkC(═O)OR a , or oxo;

R a is independently H or R b ;

R b is independently phenyl, benzyl, or C 1-6 alk, wherein said phenyl, benzyl, and C 1-6 alk are substituted by 0, 1, 2 or 3 substituents which are C 1-4 alk, C 1-3 haloalk, —OH, —OC 1-4 alk, —NH 2 , —NHC 1-4 alk, —OC(═O)C 1-4 alk, or —N(C 1-4 alk)C 1-4 alk; and

R c is independently a carbon-linked or nitrogen-linked saturated, partially-saturated or unsaturated 3-, 4-, 5-, 6-, or 7-membered monocyclic ring or a saturated, partially-saturated or unsaturated 6-, 7-, 8-, 9-, 10-, 11-, or 12-membered bicyclic ring, said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 atoms which are O or S; R c is independently substituted by 0, 1, 2 or 3 R 10 groups.

2. The compound as in claim 1 wherein the group

3. The compound as in claim 1 wherein E, X, Y, and Z is independently N or CR 4 ; wherein 1 or 2 of E, X, Y, and Z are N; selected from the group consisting of

4. The compound as in claim 1 wherein the group —W-T-D<is selected from the group consisting of —N═CR 5 —N<; NR 7 —N═C<; NR 7 —(C═O)—N<; NR 7 —CR 6 R 7 —(C═O)—N<; and —NR 7 —(SO 2 )—N<.

5. The compound as in claim 1 wherein the group —W-T-D<is —NR 7 —(C═O)—N<.

6. The compound as in claim 5 wherein R 7 is H, C 1-4 alk or a saturated 3-, 4-, 5- or 6-membered monocyclic ring; or unsaturated 5- or 6-membered monocyclic ring; wherein each said ring contains 0, 1, or 2 N atoms and 0, 1, or 2 O or S atoms; wherein said R 7 C 1-4 alk or monocyclic ring is independently substituted by 0, 1, 2 or 3 R 9 groups.

7. The compound as in claim 1 wherein the sum of p and q is 2.

8. The compound as in claim 1 wherein R 1 is a saturated, partially-saturated or unsaturated 9- or 10-membered bicyclic ring wherein each R 1 is selected from

and wherein each R 1 is independently substituted by 0, 1, 2 or 3 R 9 groups.

9. The compound as in claim 1 wherein R 1 is unsaturated 9- or 10-membered bicyclic ring, wherein each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 O or S atoms; wherein each R 1 is independently substituted by 0, 1, 2 or 3 R 9 groups.

10. The compound as in claim 1 wherein R 1 is pyridothiazolyl, pyridooxazolyl, pyridimidazolyl, pyrazimidazolyl, pyrimidimidazolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, quinolinyl, isoquinolinyl, quinazolinyl, quinaxolinyl, naphthyridinyl, pyridimidazolyl, pyridopyrazolyl, or thiazolo[5,4-b]pyridinyl.

11. The compound as in claim 1 wherein R 1 is benzoxazolyl, quinazolinyl, quinolinyl, benzimidazolyl, benzthiazolyl, 1,5-naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, or 1,8-naphthyridinyl.

12. The compound as in claim 1 wherein R 2 is H or methyl.

13. The compound as in claim 1 wherein m is 0.

14. The compound as in claim 1 wherein each R 3a and R 3c is H and m is 0.

15. The compound as in claim 1 wherein J is —CH or —CCH 3 ; and G is R 1 or —NR 1 R 2 .

16. A pharmaceutical composition comprising a compound, or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as in claim 1 and a pharmaceutically-acceptable excipient.

17. The compound, or a pharmaceutically-acceptable salt thereof, as in claim 1 , selected from the group consisting of:

N-(trans-3-(2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(Trans-3-(2-cyclopropyl-3h-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,5-naphthyridin-2-amine;

N-(Trans-3-(2-cyclopropyl-3h-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)thiazolo[5,4-b]pyridin -2-amine;

N-(Trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(Trans-3-(2-cyclopropyl-3h-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinolin-2-amine;

N-(Trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-6-fluoroquinolin-2-amine;

N-(Trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinazolin-2-amine;

N-(Cis-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(trans-3-(2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(Trans-3-(2-cyclopropyl-3h-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,8-naphthyridin-2-amine;

N-(Trans-3-(2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinazolin-2-amine;

N-(trans-3-(8-cyclopropyl-9H-purin-9-yl)cyclobutyl)quinazolin-2-amine;

N-(trans-3-(3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(Trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)benzo[d]oxazol-2-amine;

N-(Trans-3-(2-cyclopropyl-3h-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,7-naphthyridin-2-amine;

7-Chloro-N-(trans-3-(2-(tetrahydro-2H-pyran-4-yl)-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinoxalin-2-amine;

N-(Trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,7-naphthyridin-2-amine;

7-Chloro-N-(trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinoxalin-2-amine;

7-Chloro-N-(trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinolin-2-amine;

N-(Trans-3-(6-chloro-9H-purin-9-yl)cyclobutyl)quinazolin-2-amine;

N-(Trans-3-(3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinazolin -2-amine;

9-(Trans-3-(quinazolin-2-ylamino)cyclobutyl)-8-(trifluoromethyl)-9H-purin-6-ol;

N-(Trans-3-(6-morpholino-9H-purin-9-yl)cyclobutyl)quinazolin-2-amine;

Methyl 4-(9-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-8-(trifluoromethyl)-9H-purin-6-yl)benzoate;

Methyl 4-(9-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-9H -purin-6-yl)benzoate;

N-(Trans-3-(2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)thiazolo[4,5-b]pyridin-2-amine;

7-Chloro-N-(trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)quinazolin-2-amine;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

1′-(Trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)spiro[cyclopropane-1,3′-pyrrolo[2,3-b]pyridin]-2′(1 ′H)-one;

1-(trans-3-((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

1′-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-5′-fluorospiro[cyclopropane-1,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one;

5-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

1′-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)spiro[cyclobutane-1,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one;

1′-(Trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)spiro[cyclopentane-1,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one;

1′-(Trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

1-(Cis-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3,3-dimethyl-1H pyrrolo[2,3-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1-cyclopropyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-6-fluoro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1-cyclopropyl-6-fluoro-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1-cyclopentyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3-cyclopropyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

9-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-7-cyclopropyl-7H-purin-8(9H)-one;

3-(trans-3-((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

9-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-7-methyl-7H-purin-8(9H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3-methyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

3-(trans-3-(quinolin-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

9-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-7H-purin-8(9H)-one;

3-(trans-3-((4-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-((5-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)oxazolo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-((7-fluoroquinolin-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(cis-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-((7-methoxyquinolin-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(cis-3-(benzo[d]thiazol-2-yl(methyl)amino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-((7-fluoroquinazolin-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

N-(trans-3-(3-amino-1H-pyrazolo[3,4-b]pyridin-1-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(trans-3-(3-cyclopropyl-1H-pyrazolo[3,4-b]pyridin-1-yl)cyclobutyl)benzo[d]thiazol-2-amine;

N-(trans-3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)cyclobutyl)benzo[d]thiazol-2-amine;

1-(4-((1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)piperidin-1-yl)ethanone;

N-(3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,3-benzothiazol-2-amine;

1H-benzimidazol-2-yl(3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)methanol;

N-(cis-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,3-benzothiazol-2-amine;

N-(trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-1,3-benzothiazol-2-amine;

N-(trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl)-3,4-dihydro-2-quinoxalinamine;

4-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

7,7-dimethyl-5-(trans-3-(thiazolo[5,4-b]pyridin-2-ylamino)cyclobutyl)-5h-pyrrolo[2,3-b]pyrazin-6(7h)-one;

3-(cis)-3-(benzo[d]thiazol-2-ylamino)cyclobutyl-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-(benzo[d]oxazol-2-ylamino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

3-(trans-3-((5-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-methyl-3-(trans-3-((1-methyl-1H-benzo[d]imidazol-2-yl)oxy)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-methyl-3-(trans-3-((1-methyl-1H-benzo[d]imidazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

7-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one;

5,5-dimethyl-7-(trans-3-(1,5-naphthyridin-2-ylamino)cyclobutyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one;

3-(trans-3-((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

5-(trans-3-((5-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

5-(trans-3-((5-fluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

1-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one;

7-(trans-3-((6-fluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-5,5-dimethyl-2-(methylsulfanyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one;

7-(trans-3((6-fluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one;

7,7-dimethyl-5-(trans-3-((1-methyl-1H-benzo[d]imidazol-2-yl)amino)cyclobutyl)-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

5-(trans-3-((1,8-naphthyridin-2-yl)amino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

5-(trans-3-((1,5-naphthyridin-2-yl)amino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

3,3-dimethyl-1-(trans-3-(2-quinazolinylamino)cyclobutyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

1-(trans-3-(1,3-benzoxazol-2-ylamino)cyclobutyl)-3,3-dimethyl -1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

5-(trans-3-((5,6-difluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

5-(trans-3-((4,6-difluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

5-(trans-3-((6-methoxy-1,3-benzothiazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

7,7-dimethyl-5-(trans-3-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)cyclobutyl)-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

1-methyl-3-(trans-3-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-cyclopropyl-3-(trans-3-((7-fluoro-2-quinazolinyl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

5-(trans-3-((7-fluoro-2-quinazolinyl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

1-cyclopropyl-3-(trans-3-((6-fluoro-1,3-benzoxazol-2-yl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

5-(trans-3-((6-fluoro-1,3-benzoxazol-2-yl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

1-cyclopropyl-3-(trans-3-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-cyclopropyl-3-(trans-3-((6-fluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

(R)-1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3-hydroxy-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(S)-1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3-hydroxy-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(3R)-1-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-3-hydroxy-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(3s)-1-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-3-hydroxy-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

1-cyclopropyl-3-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-cyclopropyl-3-(trans-3-((5-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-cyclopropyl-3-(trans-3-((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

7,7-dimethyl-5-(3-(quinolin-2-ylamino)cyclobutyl)-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

7,7-dimethyl-5-(trans-3-(2-quinolinylamino)cyclobutyl)-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

5-(trans-3-((6-fluoro-2-quinolinyl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

5-(trans-3-((7-fluoro-2-quinolinyl)amino)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

5-(trans-3-(1,3-benzothiazol-2-yloxy)cyclobutyl)-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-b]pyrazin-6-one;

6-fluoro-1-methyl-3-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3,3,5-trifluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

6-fluoro-3-(trans-3-((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

6-fluoro-3-(trans-3-((5-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-5-chloro-3,3-difluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

1-(trans-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3,3-difluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

1-cyclopropyl-3-(trans-3((6-fluorobenzo[d]thiazol-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

1-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-3,3-difluoro-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

5-(cis-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-7,7-dimethyl-5H-pyrrolo[2,3-b]pyrazin-6(7H)-one;

1-(cis-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)-3-methyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

n-(cis-3-(7,7-dimethyl-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-b]pyrazin-5-yl)cyclobutyl)-1H-benzo[d]imidazole-2-carboxamide;

1-cyclopropyl-3-(trans-3-(quinazolin-2-ylamino)cyclobutyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

1-(trans-3-(benzo[d]oxazol-2-ylamino)cyclobutyl)-3-cyclopropyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

1-cyclopropyl-3-(trans-3-((5-fluoro-1,3-benzothiazol-2-yl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-cyclopropyl-3-(trans-3-(1,8-naphthyridin-2-ylamino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-cyclopropyl-3-(trans-3-((6-methoxy-1,3-benzothiazol-2-yl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-cyclopropyl-3-(trans-3-(2-quinolinylamino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-cyclopropyl-3-(trans-3-((1-methyl-1H-benzimidazol-2-yl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;

1-(trans-3-((6-chlorobenzo[d]oxazol-2-yl)amino)cyclobutyl)-3-cyclopropyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one;

1-(trans-3-(1,3-benzothiazol-2-ylamino)cyclobutyl)-5-bromo-3-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one; and

5-bromo-3-cyclopropyl-1-(trans-3-((7-fluoro-2-quinazolinyl)amino)cyclobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one.