IP Library › Granted Patent US 9,186,310
Granted Patent B2
US 9,186,310 · App. 14/363,920 · Granted Nov 17, 2015

Methods and compositions for alteration of skin pigmentation

Inventor: John E. Kulesza (Berlin, CT)
A61K8/55A61K8/362A61K8/365A61K8/675A61K9/0014A61K31/19A61K31/192A61K31/194A61K31/455A61K31/6615A61Q19/02A61K2800/592A61K2800/782
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,186,310
App. No.
14/363,920
Granted
Nov 17, 2015
Kind
B2
Abstract

Compositions are provided that possess levels of phytic acid and optionally a hydroxy acid and/or azelaic acid that act synergistically with the phytic acid to reduce melanin levels in skin. Improved reduction in melanin levels and hyperpigmentation are achieved at low levels of azelaic acid and phytic acid such that greater comfort and reduced irritation are observed at an administration site. Processes of reducing melanin levels or treating hyperpigmentation are provided by topically administering compositions of the invention.

Claims (26)

1. A composition for promoting a reduction in skin pigmentation comprising:

azelaic acid at 0.1 to 1.5 percent by weight, azelaic acid is alone or in combination with one or more hydroxy acids; and

phytic acid present at 0.1 to 8 percent by weight;

wherein said azelaic acid and said phytic acid are present in synergistic concentrations to reduce melanin levels in a melanin containing cell when contacted to said cell.

2. The composition of claim 1 comprising both azelaic acid and one or more hydroxy acids.

3. The composition of claim 1 wherein said composition is anhydrous.

4. The composition of claim 1 wherein at least one of said hydroxy acids is an alpha hydroxy acid.

5. The composition of claim 1 wherein said hydroxy acid is glycolic acid, mandelic acid, or combinations thereof.

6. The composition of claim 1 wherein said azelaic acid is present at 1.0 to 10 percent by weight.

7. The composition of claim 1 wherein said azelaic acid is present at 1.0 percent to 5.0 percent by weight.

8. The composition of claim 1 wherein said phytic acid is present at 1.0 percent to 5.0 percent by weight.

9. The composition of claim 1 wherein said azelaic acid and said phytic acid are each present at from 0.5 percent to 5 percent by weight.

10. The composition of claim 1 further comprising one or more vitamins.

11. The composition of claim 10 wherein said vitamin is niacinamide.

12. A process of reducing melanin content in a cell comprising

contacting a cell with a composition comprising

azelaic acid present at 0.1 to 15 percent by weight; and

phytic acid present at 0.1 to 10 percent by weight;

said azelaic acid and phytic acid present in synergistic concentrations to reduce melanin content in said cell, and

reducing melanin content in said cell by said step of contacting.

13. The process of claim 12 wherein said azelaic acid is present at 1.0 to 10 percent by weight.

14. The process of claim 12 wherein said azelaic acid is present at 1.0 percent to 5 percent by weight.

15. The process of claim 12 wherein said phytic acid is present at 1.0 percent to 5 percent by weight.

16. The process of claim 12 wherein said azelaic acid and said phytic acid are each present at from 1.0 percent to 5% by weight.

17. The process of claim 12 wherein said composition further comprises one or more hydroxy acids.

18. The process of claim 17 wherein said hydroxy acid is mandelic acid, glycolic acid, or combinations thereof.

Continuity (2)
Provisional Application 61568469 · Dec 8, 2011
Related Publication 20140377200A1 · Dec 25, 2014