Combinations of serotonin receptor agonists for treatment of movement disorders
The present invention relates to the use of 5-HT1 agonists in pharmaceutical compositions, compounds and methods for treatment of movement disorders related to neurological dysfunctions. The invention is particularly relevant for treatment of patients suffering from tardive dyskinesia, Parkinson's disease and associated disorders thereof. Kits of parts comprising the 5-HT1 agonist compounds or pharmaceutical compositions according to the present invention, as well as methods of preparation are also provided by the present invention.
1. A method for treatment or alleviation of a movement disorder selected from the group consisting of tardive dyskinesia, akathisia, Parkinson's disease and movement disorders associated with Parkinson's disease, to an individual in need thereof, comprising:
one or more steps of administration of a pharmaceutical composition comprising a synergistically effective amount of a combination of zolmitriptan, or a pharmaceutically acceptable salt thereof, and buspirone, or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 , wherein the zolmitriptan is administered in doses of 0.5-60 mg/day.
3. The method according to claim 1 , wherein the buspirone is administered in doses of 0.5-100 mg/day.
4. The method according to claim 1 , wherein said pharmaceutical composition further comprises one or more additional active ingredients.
5. The method according to claim 4 , wherein said one or more additional active ingredients are selected from the group consisting of: an agent increasing the dopamine concentration in the synaptic cleft, dopamine, L-DOPA and dopamine receptor agonists; agents which ameliorate symptoms of Parkinson's disease and an agent which is used for treatment of Parkinson's disease, COMT inhibitors, NMDA antagonists, MAO-B inhibitors, serotonin receptor modulators, kappa opioid receptor agonists, GABA modulators, modulators of neuronal potassium channels, glutamate receptor modulators and L-DOPA.
6. The method according to claim 5 , wherein said agent increasing the dopamine concentration in the synaptic cleft is selected from the group consisting of: dopamine, L-DOPA and dopamine receptor agonists.
7. The method according to claim 5 , wherein said agent which is used for treatment of Parkinson's disease is selected from the group consisting of: COMT inhibitors, NMDA antagonists, MAO-B inhibitors, serotonin receptor modulators, kappa opioid receptor agonists, GABA modulators, modulators of neuronal potassium channels, glutamate receptor modulators and L-DOPA.
8. The method according to claim 4 , wherein the one or more additional active ingredients comprises L-DOPA or a pharmaceutically acceptable salt thereof.
9. The method according to claim 4 , wherein said pharmaceutical composition further comprises two or more additional active ingredients, wherein at least one of the additional active ingredients is L-DOPA and wherein at least one of the additional active ingredients is a COMT inhibitor.
10. The method according to claim 4 , wherein the one or more additional active ingredients is carbidopa or benserazide.
11. The method according to claim 9 , wherein the COMT inhibitor is tolcapone or entacapone.
12. The method according to claim 1 , wherein the movement disorder is a movement disorder associated with altered synaptic dopamine levels.
13. The method according to claim 1 , wherein the movement disorder associated with Parkinson's disease is selected from the group consisting of: akinesia, bradykinesia, dyskinesia and L-DOPA induced dyskinesia.