IP Library › Granted Patent US 9,186,388
Granted Patent B2
US 9,186,388 · App. 13/885,943 · Granted Nov 17, 2015

Wnt1 for treatment of cardiovascular disorders and injuries

Inventor: Arjun Deb (Chapel Hill, NC)
Assignee: The University of North Carolina at Chapel Hill
A61K38/00A61K31/7088A61K35/36A61K35/44A61K38/16A61K48/00
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Quick Facts
Patent No.
US 9,186,388
App. No.
13/885,943
Granted
Nov 17, 2015
Kind
B2
Abstract

The present invention relates to the discovery of the role of Wnt1 in multiple cardiovascular processes, including cardiac repair, angiogenesis, and stimulation of endothelial progenitor cells. This discovery provides methods of using Wnt1 to treat cardiovascular disorders and injuries.

Claims (7)

1. A method of activating the epicardium in the ischemic heart of a subject, comprising delivering recombinant Wnt1 to the subject.

2. The method of claim 1 , wherein the Wnt1 is delivered directly to the heart of the subject.

3. The method of claim 1 , wherein delivering Wnt1 comprises delivering a Wnt1 polypeptide.

4. The method of claim 1 , wherein delivering Wnt1 comprises delivering a polynucleotide encoding a Wnt1 polypeptide.

5. The method of claim 1 , wherein delivering Wnt1 comprises delivering a cell expressing a Wnt1 polypeptide.

6. The method of claim 5 , wherein the cell is modified to recombinantly express Wnt1.

7. The method of claim 1 , wherein the subject is a human.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2015
From: DEB, ARJUN
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 036804/0598 →
CONFIRMATORY LICENSE Recorded Sep 9, 2013
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031189/0001 →
Continuity (2)
Provisional Application 61414455 · Nov 17, 2010
Related Publication 20130309211A1 · Nov 21, 2013