Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
1. A self assembling polypeptide (SAP) that forms ribbons, fibrils or fibres in a β- sheet tape-like substructure at physiological pH and physiological salt concentrations, and wherein the polypeptide is 11 residues in length and comprises P 11-8 (QQRFOWOFEQQ, SEQ ID NO: 2).
2. A dental product comprising the self-assembling polypeptide of claim 1 .
3. A dental repair or reconstruction or preventative product comprising the self-assembling polypeptide of claim 1 .
4. A tissue engineering scaffold comprising the self-assembling polypeptide of claim 1 .
5. The tissue engineering scaffold according to claim 4 , wherein the scaffold is seeded with cells.
6. A skin treatment comprising the self-assembling polypeptide of claim 1 .
7. A hair care product comprising the self-assembling polypeptide of claim 1 .
8. A bioresponsive and biocompatible surface comprising the self-assembling polypeptide of claim 1 .
9. The self assembling polypeptide of claim 1 , comprising continuous filament yarns, staple, floc, cord, or fabric.
10. The self assembling polypeptide of claim 1 , further comprising a polymer.
11. The self assembling polypeptide of claim 1 , wherein the physiological pH is about 7.5.
12. The self assembling polypeptide of claim 1 , wherein the physiological salt concentration is about 145 mM NaCl.
13. A composition, comprising:
ribbons, fibrils or fibres, wherein each of the ribbons, fibrils or fibres has an antiparallel arrangement of peptides in a β-sheet tape-like substructure at physiological pH and physiological salt concentrations, wherein the composition comprises peptide P 11-8 (QQRFOWOFEQQ, SEQ ID NO: 2); and a physiological concentration of salt.
14. The composition of claim 13 , wherein the composition comprises fibrils, and wherein the fibrils are comprised in a network of fibrils interconnected at fibre-like junctions.
15. A dental product comprising the composition of claim 13 .
16. A dental repair or reconstruction or preventative product comprising the self-assembling polypeptide of claim 13 .
17. The composition of claim 15 , wherein the composition is in the form of a tissue engineering scaffold.
18. The composition according to claim 17 , comprising the scaffold seeded with cells.
19. A skin treatment comprising the composition of claim 13 .
20. A hair care product comprising the composition of claim 13 .
21. A bioresponsive and biocompatible surface comprising the composition of claim 13 .
22. The composition of claim 13 , wherein the composition comprises continuous filament yarns, staple, floc, cord, or fabric.
23. The composition of claim 13 , further comprising a polymer.
24. The composition of claim 13 , wherein the physiological pH is about 7.5.
25. The composition of claim 13 , wherein the physiological salt concentration is about 145 mM NaCl.
26. A method of forming a tape, comprising contacting the SAP of claim 1 with an ionic aqueous medium, thereby forming a tape.
27. A method of forming a gel, comprising contacting the SAP of claim 1 with an ionic aqueous medium, thereby forming a gel.
28. A method of forming a tape, comprising contacting the composition of claim 13 with an ionic aqueous medium, thereby forming a tape.
29. A method of forming a gel, comprising contacting the composition of claim 13 with an ionic aqueous medium, thereby forming a gel.