Therapeutic composition for treating cancers
Disclosed herein is a composition that includes a novel combination of triterpenoids for the treatment or prophylaxis of a cancer. The triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS). The composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia.
1. A pharmaceutical composition comprising,
a therapeutically effective amount of a mixture of triterpenoids that comprises:
10 to 30% (wt %) of ganoderic acid S (GAS),
20-75% (wt %) of ganoderic acid T (GAT),
0.5 to 20% (wt %) of the combination of ganoderic acid Me (GAMe) and ganoderic acid R (GAR), and
0.5 to 20% (wt %) of ganodermic acid S (GMAS); and
a pharmaceutically acceptable excipient.
2. A method of treating a cancer in a subject comprising administering to the subject an effective amount of the pharmaceutical composition of claim 1 , wherein the cancer is selected from the group consisting of colon cancer, hepatic cancer, breast cancer, lung cancer and leukemia.
3. The method of claim 2 , wherein the lung cancer is resistant to gefitinib.
4. The method of claim 2 , wherein the subject is a human.