Combination products including bioactive glass and collagen and kits including the same

1. A combination product consisting of:

a porous and nonporous bioactive glass, and

collagen, and

optionally, at least one therapeutic agent, protein, and glycosaminoglycan,

wherein the combination product is free from calcium phosphate.

2. The combination product of claim 1 , wherein the bioactive glass is present in a weight ratio of more than 80% and including and up to 97% in proportion to the total weight of the bioactive glass and the collagen.

3. The combination product of claim 1 , wherein the bioactive glass is present in an amount from 85 wt. % to 97.5%.

4. The combination product of claim 1 , wherein the combination product is in a form of a packable graft.

5. The combination product of claim 4 , wherein the combination product consists of 75-95 wt. % bioactive glass and 5-25 wt. % collagen.

6. The combination product of claim 4 , wherein the combination products consists of 85 wt. % bioactive glass and 15 wt. % collagen.

7. The combination product of claim 4 , wherein the bioactive glass comprises 55-65% bioactive glass having 1000-2000 um particle size, 10-20% bioactive glass having 90-710 um particle size, and 10-20% bioactive glass having 32-125 um particle size.

8. The combination product of claim 4 , wherein the bioactive glass comprises 60% bioactive glass having 1000-2000 um particle size, 12.5% bioactive glass having 90-710 um particle size, and 12.5% bioactive glass having 32-125 um particle size.

9. The combination product of claim 7 , wherein the bioactive glass having the 1000-2000 um particle size is porous.

10. The combination product of claim 1 , wherein the combination product is in a form of a collagen bioactive glass composite.

11. The combination product of claim 10 , wherein the combination product consist of 75-95 wt. % bioactive glass and 5-25 wt. % collagen.

12. The combination product of claim 10 , wherein the combination product consist of 90 wt. % bioactive glass and 10 wt. % collagen.

13. The combination product of claim 10 , wherein the bioactive glass comprises 55-65% bioactive glass—having 1000-2000 um particle size, 10-20% bioactive glass having 90-710 um particle size, and 10-20% bioactive glass having 32-125 um particle size.

14. The combination product of claim 10 , wherein the bioactive glass comprises 60% bioactive glass having 1000-2000 um particle size, 15% bioactive glass having 90-710 um particle size, and 15% bioactive glass having 32-125 um particle size.

15. The combination product of claim 13 , wherein the bioactive glass having 1000-2000 um particle size is porous.

16. The combination product of claim 1 , wherein the combination product is in a form of a strip.

17. The combination product of claim 16 , wherein the combination product consist of 85-97 wt. % bioactive glass and 3-15 wt. % collagen.

18. The combination product of claim 16 , wherein the combination product consist of 95 wt. % bioactive glass and 5 wt. % collagen.

19. The combination product of claim 16 , wherein the combination product consist of 97.5 wt. % bioactive glass and 2.5 wt. % collagen.

20. The combination product of claim 16 , wherein the bioactive glass comprises 53.5-73.5% bioactive glass having 1000-2000 um particle size, 10-20% bioactive glass having 90-710 um particle size, 10-20% bioactive glass having 32-125 um particle size.

21. The combination product of claim 16 , wherein the bioactive glass comprises 63.33% bioactive glass having 1000-2000 um particle size, 15.83% bioactive glass having 90-710 um particle size, 15.83% bioactive glass having 32-125 um particle size.

22. The combination product of claim 20 , wherein the bioactive glass having the 1000-2000 um particle size is porous.

23. The combination product of claim 16 , wherein the bioactive glass comprises 64.68% 1000-2000 micrometer bioactive glass, 16.16% 90-710 micrometer bioactive glass, 16.16% 32-125 micrometer bioactive glass.

24. The combination product of claim 23 , wherein the bioactive glass having 1000-2000 um particle size is porous.

25. A kit comprising the combination product of claim 4 and a packaging.

26. The kit of claim 25 , wherein the packaging is a double peel packaging.

27. The kit of claim 25 , wherein the packaging comprises

an inner tray, wherein the combination product is contained within the inner tray,

an inner tray lid,

an outer tray, wherein the inner tray is placed in the outer tray, and

an outer tray lid.

28. The kit of claim 25 , further comprising a dispenser box.

29. The kit of claim 27 , further comprising a syringe.

30. The kit of claim 29 , wherein the combination product is disposed within the syringe.

31. The kit of claim 30 , wherein the syringe comprises a removable cap.

32. The kit of claim 31 , wherein the syringe is placed in the inner tray.

33. The kit of claim 25 , further comprising a syringe comprising a removable cap, wherein the syringe is sealed in a pouch.

34. A kit comprising the combination product of claim 10 and a packaging.

35. The kit of claim 34 , wherein the packaging is a double peel packaging.

36. The kit of claim 34 , wherein the packaging comprises

an inner tray, wherein the combination product is contained within the inner tray,

an inner tray lid,

an outer tray, wherein the inner tray is placed in the outer tray, and

an outer tray lid.

37. The kit of claim 34 , further comprising a dispenser box.

38. A kit comprising the combination product of claim 16 and a packaging.

39. The kit of claim 38 , wherein the packaging is a double peel packaging.

40. The kit of claim 38 , wherein the packaging comprises

an inner tray, wherein the combination product is contained within the inner tray,

an inner tray lid,

an outer tray, wherein the inner tray is placed in the outer tray, and

an outer tray lid.

41. The kit of claim 40 , further comprising a dispenser box.