IP Library › Granted Patent US 9,199,935
Granted Patent B2
US 9,199,935 · App. 14/246,879 · Granted Dec 1, 2015

Pharmaceutically active piperidine derivatives

Inventors: Terence D. Butters (Oxford, GB); Raymond A. Dwek (Oxford, GB); George W. J. Fleet (Oxford, GB); Michael Glen Orchard (Abingdon, GB); Frances Mary Platt (Oxford, GB)
Assignee: Acetelion Pharmaceuticals Ltd.
C07D211/46A61K31/445A61K31/451A61K45/06C07H15/12
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Quick Facts
Patent No.
US 9,199,935
App. No.
14/246,879
Granted
Dec 1, 2015
Kind
B2
Abstract

Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.

Claims (2)

1. The compound which is (2S,3R,4R,5S)-1-pentyl-2-(hydroxymethyl)-3, 4, 5-piperidinetriol, in free or pharmaceutically acceptable salt form.

2. A pharmaceutical composition comprising compound of claim 1 , in free or pharmaceutically acceptable salt form, together with one or more pharmaceutically acceptable carriers, excipients and/or diluents.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBERS 6291657, 8729099, 15526983, 15528407 PREVIOUSLY RECORDED ON REEL 046723 FRAME 0696. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF THE ASSIGNOR'S INTEREST. Recorded Aug 30, 2018
From: ACTELION PHARMACEUTICALS LTD.
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 046985/0911 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 28, 2018
From: ACTELION PHARMACEUTICALS LTD.
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 046723/0696 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2015
From: BUTTERS, TERENCE D.; DWEK, RAYMOND A.; FLEET, GEORGE; PLATT, FRANCES M.
To: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Reel/Frame 034956/0175 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2015
From: ORCHARD, MICHAEL G.
To: OXFORD GLYCOSCIENCES (UK) LIMITED
Reel/Frame 034956/0202 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2015
From: UCB S.A.
To: ACTELION PHARMACEUTICALS LTD
Reel/Frame 034956/0237 →
BUSINESS SALE AGREEMENT Recorded Feb 13, 2015
From: OXFORD GLYCOSCIENCES (UK) LIMITED
To: UCB S.A.
Reel/Frame 034991/0345 →
Priority Claims (1)
GB 0100889.5 · Jan 12, 2001 · national
Continuity (4)
Continuation 11196153 · Aug 3, 2005
Division 10618165 · Jul 11, 2003
Continuation In Part PCTGB0200106 · Jan 11, 2002
Related Publication 20140303208A1 · Oct 9, 2014