IP Library › Granted Patent US 9,199,997
Granted Patent B2
US 9,199,997 · App. 14/360,725 · Granted Dec 1, 2015

Purinone derivative hydrochloride

Inventors: Shingo Yamamoto (Osaka, JP); Toshio Yoshizawa (Osaka, JP)
Assignee: ONO PHARMACEUTICAL CO., LTD.
C07D473/00A61K31/522C07D473/34
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Quick Facts
Patent No.
US 9,199,997
App. No.
14/360,725
Granted
Dec 1, 2015
Kind
B2
Abstract

The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Claims (1)

1. 6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2014
From: YAMAMOTO, SHINGO; YOSHIZAWA, TOSHIO
To: ONO PHARMACEUTICAL CO., LTD.
Reel/Frame 032967/0308 →
Priority Claims (1)
JP 2011-259662 · Nov 29, 2011 · national
Continuity (1)
Related Publication 20140330015A1 · Nov 6, 2014