Tape-type fluorine preparation using biodegradable polymer and method of preparing the same
View Patent ↗Provided are a tape-type fluorine preparation using a biodegradable polymer and a method of preparing the same, and preferably, a tape-type fluorine preparation which is attached to teeth to gradually release fluorine, thereby maintaining a suitable fluorine concentration in an oral cavity, and self-degraded after a certain amount of time, and a method of preparing the same. The tape-type fluorine preparation includes a pressure-sensitive adhesive sheet containing fluorine and capable of being attached to teeth, and the pressure-sensitive adhesive sheet is formed of a biodegradable hydrophilic polymer in an oral cavity to reduce a rate at which the fluorine is released.
1. A method of preparing an adhesive sheet containing fluorine, the method comprising:
mixing 10 to 25 parts by weight of a biodegradable hydrophilic polymer and 100 parts by weight of a solvent to obtain a polymer solution;
adding 1 to 10 parts by weight of a plasticizer to 100 parts by weight of the polymer solution and stirring the resulting polymer solution to which the plasticizer is added;
adding 1 to 10 parts by weight of a fluorine compound and 2 to 20 parts by weight of a pressure-sensitive adhesive to 100 parts by weight of the polymer solution to which the plasticizer is added and stirring the resulting polymer solution to which the fluorine compound and the adhesive are added; and
plasticizing the polymer solution to which the plasticizer, fluorine compound and adhesive are added to form the adhesive sheet having a thickness of 10 to 30 μm,
wherein the hydrophilic polymer is a mixture of polyvinyl alcohol (PVA) and sodium carboxymethyl cellulose (sodium CMC) configured for slow releasing of fluorine from the adhesive sheet containing fluorine,
wherein the hydrophilic polymer has a weight ratio of polyvinyl alcohol to sodium carboxymethyl cellulose of 1:0.3, and
wherein the polyvinyl alcohol is completely saponified and has a molecular weight of 1700, and the sodium carboxymethyl cellulose has a viscosity of 400 cp.
2. The method according to claim 1 , wherein the fluorine compound is one selected from the group of tin fluoride, sodium monofluorophosphate, and calcium monofluorophosphate.