Dihydrothienopyrimidines

1. A compound of the formula I

wherein

A is selected from the group A a consisting of

a heteroaryl group with 5 or 6 ring atoms containing one to three heteroatoms independently selected from N, O, S,

wherein above mentioned heteroaryl groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-, C 1-4 -alkyl-O—C 1-3 -alkyl-, C 1-4 -alkyl-O— which is optionally fluorinated with 1 to 9 fluorine atoms and (C 1-4 -alkyl) 3 Si—;

B is selected from the group B a consisting of

wherein above mentioned phenyl-, pyridinyl-, pyrimidinyl-, pyridazinyl and pyrazinyl groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of HO—, halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-O— and C 1-6 -alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms;

D is selected from the group D a consisting of

a mono- or bicyclic carbocyclus consisting of 3 to 10 carbon atoms wherein one of the rings may be an aromatic ring, or

a 4- to 12-membered mono-, bicyclic or bridged heterocyclyl group, wherein above mentioned ring D a may optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-, heterocyclyl, aryl, aryl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl-, HC(O)—, C 1-6 -alkyl-C(O)—, C 3-6 -cycloalkyl-C(O)—, aryl-C(O)—, C 1-4 -alkyl-O—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, HO—, oxo, C 1-6 -alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-O—, heterocyclyl-O—, aryl-O—, heteroaryl-O—, H 2 N—, (C 1-4 -alkyl) 2 N—, azetidinyl, pyrrolidinyl and (C 1-4 -alkyl)(C 1-3 -alkyl-C(O))N—,

wherein above mentioned aryl-C(O)—, aryl-O—, aryl, aryl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl- and heteroaryl-O— groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 3 C—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4- alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl-which is optionally fluorinated with 1 to 13 fluorine atoms;

W is selected from the group W a consisting of

—(R 7 )N— and —O—;

X is selected from the group X a consisting of

—S—, —S(O)— and —S(O) 2 —;

R 1 is selected from the group R 1a consisting of

H, C 1-6 -alkyl-, C 2-6 -alkenyl-, C 2-6 -alkynyl-, carbocyclyl, carbocyclyl-C 1-3 -alkyl-, C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl, aryl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl-, R 4 R 5 N—, R 4 R 5 N—C 1-3 -alkyl- and R 4 O—,

wherein above mentioned C 2-6 -alkenyl-, C 2-6 -alkynyl-, C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl, aryl-C 1-3 -alkyl-, heteroaryl and heteroaryl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4- alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, and

wherein above mentioned C 1-6 -alkyl-, carbocyclyl and carbocyclyl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, HO—, oxo, C 1-6 -alkyl-, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—, oxetanyl-O—, tetrahydrofuryl-O— and tetrahydropyranyl-O—;

R 2 , R 3 are selected independently of each other from the group R 2a /R 3a consisting of

H, halogen, C 1-6 -alkyl-, C 3-6 -cycloalkyl-, aryl, aryl-C 1-3 -alkyl-, HO—, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—,

wherein above mentioned aryl, and the aryl moiety of the aryl-C 1-3 -alkyl-group may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4- alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, and

wherein the alkyl moieties of above mentioned C 1-6 -alkyl-, C 3-6 -cycloalkyl-, aryl-C 1-3- alkyl-, C 1-6 -alkyl-O— and C 3-6 -cycloalkyl-O-groups may optionally be substituted with 1-13 fluorine atoms, or

R 2a and R 3a form together with the carbon atom to which they are attached an oxo group;

R 4 , R 5 are selected independently of each other from the group R 4a /R 5a consisting of

H, C 1-6 -alkyl-, carbocyclyl, carbocyclyl-C 1-3 -alkyl-, carbocyclyl-O—C 2-4 -alkyl-, heterocyclyl, heterocyclyl-C 1-6 -alkyl-, heterocyclyl-O—C 2-4 -alkyl-, aryl, aryl-C 1-3 -alkyl-, aryl-O—C 2-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl- and heteroaryl-O—C 2-3 -alkyl-,

wherein above mentioned C 1-6 -alkyl-, carbocyclyl, carbocyclyl-C 1-3 -alkyl-, carbocyclyl-O—C 2-4 -alkyl-, heterocyclyl, heterocyclyl-C 1-6 -alkyl- or heterocyclyl-O—C 2-4 -alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, HO—, oxo, C 1-4 -alkyl-O— which is optionally fluorinated with 1 to 9 fluorine atoms, C 1-4 -alkyl-O—C(O)—, HO—C 1-4 -alkyl-, C 1-4 -alkyl-O—C 1-4 -alkyl-, heterocyclyl, (C 1-4 -alkyl) 2 N—, (C 1-3 -alkyl) 2 N—C(O)—, and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms,

wherein above mentioned aryl-, aryl-C 1-3 -alkyl-, aryl-O—C 2-3 -alkyl-, heteroaryl-, heteroaryl-C 1-3 -alkyl- and heteroaryl-O—C 2-3 -alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, (R 6 ) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, or

R 4a and R 5a form together with the nitrogen atom to which they are attached a 4-12-membered mono-, bicyclic or bridged ring system optionally containing one or two double bonds and/or one aromatic ring and optionally containing one or two additional heteroatoms selected from the group consisting of —O—, —S—, —S(O)—, —S(O) 2 —, —N(R 6 )—,

wherein 2 geminal hydrogen atoms of the 4-12-membered mono- or bicyclic ring system may be replaced by a —(CH 2 ) 1-5 — group and

wherein one —(CH 2 )— group of the —(CH 2 ) 1-5 — group may be replaced by —O— or —N(R 6 )— and

wherein above mentioned 4-12-membered mono-, bicyclic or bridged ring system may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen, cyano, aryl, heteroaryl, aryl-C 1-3 -alkyl-, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, heterocyclyl, HO—, oxo, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—, C 1-4 -alkyl-O—C(O)—, HO—C 1-4 -alkyl-, C 1-4 -alkyl-O—C 1-4 -alkyl-, C 3-6 -cycloalkyl-O—C 1-4 -alkyl-, heterocyclyl-O—, heterocyclyl-O—C 1-4 -alkyl-, aryl-O—, heteroaryl-O— and (R 6 ) 2 N—,

wherein the directly above mentioned aryl, aryl-C 1-3 -alkyl-, aryl-O—, heteroaryl-O—, and heteroaryl groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, amino, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms;

R 6 is selected independently of each other from the group R 6a consisting of

H, C 1-6 -alkyl-, C 3-6 -cycloalkyl, heterocyclyl, heteroaryl, HC(O)—, C 1-6 -alkyl-C(O)—, C 3-6 -cycloalkyl-C(O)—, aryl-C(O)—, C 1-4 -alkyl-O—C(O)— and (C 1-4 -alkyl) 2 N—C(O)—,

wherein above mentioned C 1-6 -alkyl-, C 3-6 -cycloalkyl-, C 1-6 -alkyl-C(O)— and C 3-6 -cycloalkyl-C(O)— groups may optionally be substituted with 1-13 fluorine atoms and

wherein the above mentioned aryl-C(O)— and heteroaryl group may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, amino, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl-which is optionally fluorinated with 1 to 13 fluorine atoms;

R 7 is selected independently of each other from the group R 7a consisting of

H, C 1-6 -alkyl-, C 1-6 -alkyl-C(O)— and C 1-6 -alkyl-O—C(O)—,

or a salt thereof.

2. A compound according to claim 1 , wherein

A is selected from the group A b consisting of

wherein above mentioned groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen, cyano, and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms.

3. A compound according to claim 1 , wherein

A is selected from the group A c consisting of

wherein above mentioned groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen and C 1-3 -alkyl- which is optionally fluorinated with 1 to 7 fluorine atoms.

4. A compound according to claim 1 , wherein

B Is selected from the group B b consisting of

wherein above mentioned phenyl- and pyridinyl-groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of HO—, halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-O— and C 1-6 -alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms.

5. A compound according to claim 1 , wherein

D is selected from the group D b consisting of

wherein above mentioned ring system D b may optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-, heterocyclyl, aryl, aryl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl-, HC(O)—, C 1-6 -alkyl-C(O)—, C 3-6 -cycloalkyl-C(O)—, aryl-C(O)—, C 1-4 -alkyl-O—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, HO—, oxo, C 1-6 -alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-O—, heterocyclyl-O—, aryl-O—, heteroaryl-O—, H 2 N—, (C 1-4 -alkyl) 2 N—, azetidinyl, pyrrolidinyl and (C 1-4 -alkyl)(C 1-3 -alkyl-C(O))N—,

wherein above mentioned aryl-C(O)—, aryl-O—, aryl, aryl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl- and heteroaryl-O— groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 3 C—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4- alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms.

6. A compound according to claim 1 , wherein

D is selected from the group D c consisting of

wherein above mentioned ring D c may optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, cyano, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-, oxetanyl, tetrahydrofuryl, tetrahydropyranyl, phenyl, phenyl-C 1-3 -alkyl-, heteroaryl, heteroaryl-C 1-3 -alkyl-, HC(O)—, C 1-6 -alkyl-C(O)—, C 3-6 -cycloalkyl-C(O)—, phenyl-C(O)—, C 1-4 -alkyl-O—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, HO—, oxo, C 1-6 -alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms, C 3-6 -cycloalkyl-O—, oxetanyl-O—, tetrahydrofuryl-O—, tetrahydropyranyl-O—, phenyl-O—, heteroaryl-O—, H 2 N—, (C 1-4 -alkyl) 2 N—, azetidinyl, pyrrolidinyl and (C 1-4 -alkyl)(C 1-3 -alkyl-C(O))N—,

wherein above mentioned phenyl, phenyl-C 1-3 -alkyl-, heteroaryl-C 1-3 -alkyl-, phenyl-C(O)—, phenyl-O—, heteroaryl- and heteroaryl-O-group may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 C—, F 3 CO—, F 2 HCO—, FH 2 CO—, oxetanyl-O—, tetrahydrofuryl-O—, tetrahydropyranyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4- alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms.

7. A compound according to claim 1 , wherein

X is selected from the group X b consisting of

—S—, and —S(O)—.

8. A compound according to claim 1 , wherein

R 1 is selected from the group R 1b consisting of

H, C 1-6 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl-C 1-3 -alkyl-, heteroaryl-C 1-3 -alkyl-, R 4 R 5 N—, R 4 R 5 N—C 1-3 -alkyl- and R 4 O—,

wherein above mentioned C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl-C 1-3 -alkyl- and heteroaryl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, and

wherein above mentioned C 1-6 -alkyl-, C 3-7 -cycloalkyl- and C 3-7 -cycloalkyl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, HO—, oxo, C 1-6 -alkyl-, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—, oxetanyl-O—, tetrahydrofuryl-O— and tetrahydropyranyl-O—.

9. A compound according to claim 1 , wherein

R 1 is selected from the group R 1c consisting of

H, R 4 R 5 N—, R 4 R 5 N—C 1-3 -alkyl- and R 4 O—.

10. A compound according to claim 1 , wherein

R 1 is selected from the group R 1d consisting of

H, C 1-6 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl-C 1-3 -alkyl-, heteroaryl-C 1-3 -alkyl-, R 4 R 5 N— and R 4 R 5 N—C 1-3 -alkyl-,

wherein above mentioned C-linked heterocyclyl, heterocyclyl-C 1-3 -alkyl-, aryl-C 1-3 -alkyl- and heteroaryl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, heterocyclyl-O—, cyano, halogen, F 5 S—, (C 1-4 -alkyl) 3 Si—, nitro, H 2 N—, (C 1-4 -alkyl) 2 N—, (H 2 N)—C(O)—, (C 1-4 -alkyl)-HN—C(O)—, (C 1-4 -alkyl) 2 N—C(O)—, C 1-4 -alkyl-O—C 1-4 -alkyl- and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, and

wherein above mentioned C 1-6 -alkyl-, C 3-7 -cycloalkyl- and C 3-7 -cycloalkyl-C 1-3 -alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, HO—, oxo, C 1-6 -alkyl-, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—, oxetanyl-O—, tetrahydrofuryl-O— and tetrahydropyranyl-O—.

11. A compound according to claim 1 , wherein

R 2 , R 3 are selected independently of each other from the group R 2b /R 3b consisting of

H, phenyl,

wherein above mentioned phenyl group may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of C 1-4 -alkyl-O—, cyano, halogen F 3 C— and C 1-6 -alkyl-.

12. A compound according to claim 1 , wherein

R 4 , R 5 are selected independently of each other from the group R 4b /R 5b consisting of

H, C 1-6 -alkyl-, C 3-7 -cycloalkyl, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C 3-7 -cycloalkyl-O—C 2-4 -alkyl-, heterocyclyl, heterocyclyl-C 1-6 -alkyl-, aryl, aryl-C 1-3 -alkyl-, aryl-O—C 2-3 -alkyl-, heteroaryl and heteroaryl-C 1-3 -alkyl-,

wherein above mentioned C 1-6 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C 3-7 -cycloalkyl-O—C 2-4 -alkyl-, heterocyclyl or heterocyclyl-C 1-6 -alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of fluoro, HO—, oxo, C 1-4 -alkyl-O— which is optionally fluorinated with 1 to 9 fluorine atoms, HO—C 1-4 -alkyl-, C 1-4 -alkyl-O—C 1-4 -alkyl-, heterocyclyl, (C 1-3 -alkyl) 2 N—C(O)—, and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms,

wherein above mentioned aryl-, aryl-C 1-3 -alkyl-, aryl-O—C 2-3 -alkyl-, heteroaryl- and heteroaryl-C 1-3 -alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, cyano, halogen, (C 1-4 -alkyl) 2 N—C(O)—, and C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, or

R 4b and R 5b form together with the nitrogen atom to which they are attached a 4-12-membered mono-, bicyclic or bridged ring system optionally containing one double bond and/or one aromatic ring and optionally containing one additional heteroatom selected from the group consisting of —O—, —N(R 6 )—,

wherein 2 geminal hydrogen atoms of the 4-12-membered mono- or bicyclic ring may be replaced by a —(CH 2 ) 1-5 — group and

wherein one —(CH 2 )— group of the —(CH 2 ) 1-5 — group may be replaced by —O— or —N(R 6 )— and

wherein above mentioned 4-12-membered mono-, bicyclic or bridged ring system may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of fluoro, aryl, heteroaryl, C 1-6 -alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, heterocyclyl, HO—, oxo, C 1-6 -alkyl-O—, C 3-6 -cycloalkyl-O—, HO—C 1-4 -alkyl-, C 1-4 -alkyl-O—C 1-4 -alkyl-, heterocyclyl-O— and (R 6 ) 2 N—,

wherein the directly above mentioned aryl and heteroaryl groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of C 1-4 -alkyl-O—, F 3 CO—, F 2 HCO—, FH 2 CO—, cyano, halogen, (C 1-4 -alkyl) 2 N—C(O)— and C 1-6 -alkyl-which is optionally fluorinated with 1 to 13 fluorine atoms.

13. A compound according to claim 1 , wherein

R 6 is selected independently of each other from the group R 6b consisting of

H, C 1-6 -alkyl-, C 3-6 -cycloalkyl, oxetanyl, tetrahydrofuryl, tetrahydropyranyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, oxadiazolyl, oxazolyl, HC(O)—, C 1-6 -alkyl-C(O)—, C 3-6 -cycloalkyl-C(O)—, phenyl-C(O)—, C 1-4 -alkyl-O—C(O)— and (C 1-4 -alkyl) 2 N—C(O)—,

wherein above mentioned C 1-6 -alkyl-, C 3-6 -cycloalkyl-, C 1-6 -alkyl-C(O)— and C 3-6 -cycloalkyl-C(O)— groups may optionally be substituted with 1-13 fluorine atoms and

wherein the aforementioned phenyl-C(O)—, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl oxadiazolyl and oxazolyl groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of C 1-4 -alkyl-O—, F 3 C—, F 3 CO—, F 2 HCO—, FH 2 CO—, cyano, halogen, and C 1-3 -alkyl-.

14. A pharmaceutically acceptable salt of a compound according to claim 1 .

15. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.

16. A method for treating Alzheimer's disease which comprises administering to a host suffering from the same a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.