Anti-NGF antibodies and methods using same
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
1. A method of treating pain associated with peripheral neuropathy in an individual, the method comprising administering an effective amount of an anti-NGF antibody comprising three CDRs of the heavy chain variable region comprising the amino acid sequence shown in SEQ ID NO: 1 and three CDRs of the light chain variable region comprising the amino acid sequence shown in SEQ ID NO: 2 to an individual suffering from peripheral neuropathy.
2. The method of claim 1 , wherein the antibody comprises:
a heavy chain variable region comprising:
a CDR1 comprising the amino acid sequence shown in SEQ ID NO:3;
a CDR2 comprising the amino acid sequence shown in SEQ ID NO:4; and
a CDR3 comprising the amino acid sequence shown in SEQ ID NO:5, and
a light chain variable region comprising:
a CDR1 comprising the amino acid sequence shown in SEQ ID NO:6;
a CDR2 comprising the amino acid sequence shown in SEQ ID NO:7; and
a CDR3 comprising the amino acid sequence shown in SEQ ID NO:8.
3. The method of claim 2 , wherein the heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO: 1.
4. The method of claim 2 , wherein the light chain variable region comprises the amino acid sequence shown in SEQ ID NO: 2.
5. The method of claim 2 , wherein the heavy chain comprises the amino acid sequence shown in SEQ ID NO: 16.
6. The method of claim 2 , wherein the light chain comprises the amino acid sequence shown in SEQ ID NO: 17.
7. the method of claim 1 , wherein the pain is alleviated within about 24 hours after administering the anti-NGF antibody.
8. the method of claim 1 , wherein the pain is alleviated within about 4 days after administering the anti-NGF antibody.