Subfamily E simian adenoviruses A1302, A1320, A1331 and A1337 and uses thereof

1. An adenovirus having a capsid comprising a hexon protein, a penton protein, and a fiber protein, wherein said hexon protein is the hexon protein of SAdV-A1337 with the amino acids 1 to 931 of SEQ ID NO: 86, and wherein said penton protein is the penton protein of SAdV-A1337 with the amino acids 1 to 532 of SEQ ID NO: 81,

said capsid encapsidating a heterologous nucleic acid comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.

2. The adenovirus according to claim 1 , further comprising a 5′ and a 3′ adenovirus cis-element necessary for replication and encapsidation.

3. The adenovirus according to claim 1 , wherein said adenovirus lacks all or a part of the E1 gene.

4. The adenovirus according to claim 3 , wherein said adenovirus is replication—defective.

5. The adenovirus according to claim 1 , wherein said capsid is a hybrid capsid.

6. The adenovirus according to claim 5 , wherein said hybrid capsid further comprises a capsid protein from an adenovirus selected from SAdV-A 1302, SAdV-A 1320, and SAdV-A 1331.

7. A composition comprising an adenovirus according to claim 1 in a pharmaceutically acceptable carrier.

8. A composition comprising the adenovirus according to claim 1 , said adenovirus further comprising at least one simian adenovirus protein selected from the group consisting of:

E1a, SEQ ID NO: 103;

E1b, small T/19K, SEQ ID NO: 78;

E1b, large T/55K, SEQ ID NO: 98;

52/55D, SEQ ID NO: 79;

Ma, SEQ ID NO: 80;

VII, SEQ ID NO: 82;

V, SEQ ID NO: 83;

pX, SEQ ID NO: 84;

VI, SEQ ID NO: 85;

100 kD, SEQ ID NO: 88;

22 kD, SEQ ID NO: 99;

VIII, SEQ ID NO: 89;

E3/12.5 K, SEQ ID NO: 90;

CR1-alpha SEQ ID NO: 100;

gp19K, SEQ ID NO: 91;

CR1-beta, SEQ ID NO: 92;

CR1-gamma, SEQ ID NO: 93;

CR1-delta, SEQ ID NO: 94;

RID-beta, SEQ ID NO: 95; and

E3/14.7K, SEQ ID NO: 101.

9. An adenovirus having a capsid comprising a hexon protein, a penton protein, and a fiber protein, wherein said hexon protein is the hexon protein of SAdV-A1337 with the amino acids 1 to 931 of SEQ ID NO: 86, and wherein said fiber protein is the fiber protein of SAdV-A1337 with the amino acids 1 to 490 of SEQ ID NO: 96,

said capsid encapsidating a heterologous nucleic acid comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.

10. The adenovirus according to claim 9 , wherein said penton protein is the penton protein of SAdV-A1337 with the amino acids 1 to 532 of SEQ ID NO: 81.

11. The adenovirus according to claim 9 , further comprising a 5′ and a 3′ adenovirus cis-element necessary for replication and encapsidation.

12. The adenovirus according to claim 9 , wherein said adenovirus lacks all or a part of the E1 gene.

13. The adenovirus according to claim 12 , wherein said adenovirus is replication—defective.

14. The adenovirus according to claim 9 , wherein said capsid is a hybrid capsid.

15. The adenovirus according to claim 14 , wherein said hybrid capsid further comprises a capsid protein from an adenovirus selected from SAdV-A1302, SAdV-A1320, and SAdV-A1331.

16. A composition comprising an adenovirus according to claim 9 in a pharmaceutically acceptable carrier.

17. A composition comprising the adenovirus according to claim 9 , said adenovirus further comprising at least one simian adenovirus protein selected from the group consisting of:

E1a, SEQ ID NO: 103;

E1b, small T/19K, SEQ ID NO: 78;

E1b, large T/55K, SEQ ID NO: 98;

52/55D, SEQ ID NO: 79;

Ma, SEQ ID NO: 80;

VII, SEQ ID NO: 82;

V, SEQ ID NO: 83;

pX, SEQ ID NO: 84;

VI, SEQ ID NO: 85;

100 kD, SEQ ID NO: 88;

22 kD, SEQ ID NO: 99;

VIII, SEQ ID NO: 89;

E3/12.5 K, SEQ ID NO: 90;

CR1-alpha SEQ ID NO: 100;

gp19K, SEQ ID NO: 91;

CR1-beta, SEQ ID NO: 92;

CR1-gamma, SEQ ID NO: 93;

CR1-delta, SEQ ID NO: 94;

RID-beta, SEQ ID NO: 95; and

E3/14.7K, SEQ ID NO: 101.