Peptide for use in the treatment of skin conditions
The present invention relates to a peptide of the following formula (I) X 1 (X 2 )-X 3 -X 4 or a salt or solvate thereof, wherein is an amino acid comprising two or more NH-functionalities, and X 2 , X 3 , and X 4 are, independently from one another, an amino acid residue, and wherein the salt or solvate is preferably a physiologically acceptable salt or solvate.
1. A peptide of the following formula (III):
Lys(H-Asp-R 2 )-Ala-Glu (III)
or a salt thereof;
wherein R 2 is OH or NH 2 ;
wherein the C-terminal carboxyl group in Glu is optionally an amide Glu-NR 3 R 4 , and R 3 and R 4 are independently from one another H or alkyl;
and wherein the N-terminal amino group in Lys is optionally NR 5 R 6 , and R 5 and R 6 are independently from one another H or alkyl.
2. The peptide of claim 1 , wherein R 3 and R 4 are independently H or (C1-C3)alkyl.
3. The peptide of claim 1 , wherein R 3 and R 4 are H.
4. The peptide of claim 1 , wherein R 5 and R 6 are independently H or (C1-C3)alkyl.
5. The peptide of claim 1 , wherein R 5 and R 6 are H.
6. The peptide of claim 1 , wherein said peptide is contained in a cleansing agent for application to the epidermis,
wherein the cleansing agent is a soap or lotion.
7. The peptide of claim 6 , wherein the cleansing agent is contained in or applied as an aerosol.
8. The peptide of claim 1 , wherein said peptide is contained in a cleansing agent for application to the scalp, wherein the cleansing agent is a shampoo.
9. The peptide of claim 1 , wherein said peptide is contained in a cleansing agent for application to the facial skin, wherein the cleansing agent is a soap or lotion.
10. The peptide of claim 1 , wherein said peptide is contained in a formulation for application to the epidermis, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
11. The peptide of claim 10 , wherein the formulation is contained in or applied as an aerosol.
12. The peptide of claim 1 , wherein said peptide is contained in a formulation for application to the scalp, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
13. The peptide of claim 1 , wherein said peptide is contained in a formulation for application to the facial skin, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
14. A cosmetic composition comprising a peptide according to claim 1 .
15. The cosmetic composition of claim 14 , wherein said composition comprises the peptide in a concentration of from 0.005 to 20 mg/ml.
16. The cosmetic composition of claim 14 , wherein said composition comprises the peptide in a concentration of from 0.01 to 10 mg/ml.
17. The cosmetic composition of claim 14 , wherein said composition comprises the peptide in a concentration of from 0.05 to 5 mg/ml.
18. The cosmetic composition of claim 14 , wherein said composition comprises the peptide in a concentration of from 0.1 to 2 mg/ml.
19. The cosmetic composition of claim 14 , wherein said composition comprises the peptide in a concentration of from 0.2 to 1 mg/ml.
20. The composition of claim 14 , wherein said composition further comprises one or more cosmetically acceptable carriers or excipients.
21. The composition of claim 14 , wherein said composition is contained in a cleansing agent for application to the epidermis, wherein the cleansing agent is a soap or lotion.
22. The composition of claim 14 , wherein said composition is contained in a cleansing agent for application to the scalp, wherein the cleansing agent is a shampoo.
23. The composition of claim 14 , wherein said composition is contained in a cleansing agent for application to the facial skin, wherein the cleansing agent is a facial lotion.
24. The composition of claim 14 , wherein said composition is contained in a formulation for application to the epidermis, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
25. The composition of claim 14 , wherein said composition is contained in a formulation for application to the scalp, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
26. The composition of claim 14 , wherein said composition is contained in a formulation for application to the facial skin, wherein the formulation is a liquid or semisolid solution, lotion, cream, gel, or ointment.
27. A pharmaceutical composition comprising a peptide according to claim 1 .
28. The pharmaceutical composition of claim 27 , wherein said composition comprises the peptide in a concentration of from 0.01 to 100 mg/ml.
29. The pharmaceutical composition of claim 27 , wherein said composition comprises the peptide in a concentration of from 0.05 to 50 mg/ml.
30. The pharmaceutical composition of claim 27 , wherein said composition comprises the peptide in a concentration of from 0.1 to 10 mg/ml.
31. The pharmaceutical composition of claim 27 , wherein said composition comprises the peptide in a concentration of from 0.2 to 5 mg/ml.
32. The pharmaceutical composition of claim 27 , wherein said composition comprises the peptide in a concentration of from 0.5 to 2 mg/ml.
33. The composition of claim 27 , wherein said composition further comprises one or more pharmaceutically acceptable carriers or excipients.