Methods and compositions for treating or preventing narcotic withdrawal symptoms
This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.
1. A method for treating physical dependence and/or withdrawal symptoms associated with narcotic use, comprising administering to a human subject in need thereof a pharmaceutical composition consisting essentially of
(1) a narcotic compound selected from the group consisting of morphine, hydrocodone, oxycodone, hydromorphone, and oxymorphone, buprenorphine and a combination of buprenorphine and naloxone, wherein said composition is administered at a dose of between 2 and 25 mg/70 kg of subject; and
(2) a 5-HT3 receptor antagonist in a dose effective to reduce physical dependence and/or withdrawal symptoms associated with said narcotic use, wherein
the narcotic compound and the 5-HT3 receptor antagonist are co-administered.
2. The method of claim 1 further comprising the step of administering to said human subject an antiemetic antihistamine.