Medicinal agent for preventing exacerbation of malignant tumor, comprising combination of natriuretic peptide receptor GC-A and GC-B agonists
Provided are a medicinal agent which is highly safe for use as the treatment of a malignant tumor and is capable of efficiently treating a malignant tumor, that is, a medicinal agent for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, comprising at least one kind of natriuretic peptide receptor GC-A agonist and at least one kind of natriuretic peptide receptor GC-B agonist to be administered in combination; a therapeutic method comprising administering the agent; etc.
1. A method for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, comprising administering an effective amount of an atrial natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 1and an effective amount of a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7 in combination, wherein the effective amount of atrial natriuretic peptide is 0.01 μg kg −1 min −1 or more and 0.2 μg kg −1 min −1 or less and the effective amount of c-type natriuretic peptide is 0.01 μg kg −1 min −1 or more and 1.0 μg kg −1 min −1 or less, and wherein the effective amount is administered continuously for at least three days.
2. The method according to claim 1 , wherein the atrial natriuretic peptide and the c-type natriuretic peptide are administered simultaneously.
3. The method according to claim 1 , wherein the atrial natriuretic peptide and the c-type natriuretic peptide are administered in a single formulation.
4. A method for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, which comprises administering an agent which comprises atrial natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 1 as an active ingredient at an amount which is 0.01 μg kg −1 min −1 or more and 0.2 μg kg −1 min −1 or less and the agent is administered in combination with a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7 at an amount which is 0.01 μg kg −1 min −1 or more and 1.0 μg kg −1 min −1 or less and wherein the agent and c-natriuretic peptide are administered continuously for at least three days.
5. A method for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, the method comprising administering a medicinal agent which comprises a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7 as an active ingredient at an amount which is 0.01 μg kg −1 min −1 or more and 1.0 μg kg −1 min −1 or less and said medicinal agent is to be administered in combination with an atrial natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 1 at an amount which is 0.01 μg kg −1 min −1 or more and 0.2 μg kg −1 min −1 or less and wherein the medicinal agent and atrial natriuretic peptide are administered continuously for at least three days.