Treatment for oxidative stress and/or hypertension
One aspect of the invention relates to compounds, compositions and methods for treating oxidative stress and/or hypertension. In certain embodiments, the invention relates to a mixture of tempol and an angiotensin receptor blocker (ARB) and the use of said mixture to treat oxidative stress and/or hypertension. In certain embodiments, the invention relates to a tempol/ARB adduct and the use of said adduct to treat oxidative stress and/or hypertension.
1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein
Z is —O— or —N(H)—; and
R is
2. The compound of claim 1 , wherein Z is —O—.
3. The compound of claim 1 , wherein Z is —N(H)—.
4. A pharmaceutical composition, comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.
5. A method of treating oxidative stress and/or hypertension in a subject, comprising the step of administering a therapeutically effective amount of a compound of claim 1 .