Cognitive performance with sirtuin activators
Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.
1. A method for improving cognitive performance in a mammalian subject, comprising
(i) determining the cognitive performance of a mammalian subject;
(ii) comparing the cognitive performance of the mammalian subject to a control value; and
(iii) administering to the mammalian subject a SIRT1-activating agent if the cognitive performance of the mammalian subject is lower than the control value, wherein the SIRT1-activating agent is a non-naturally occurring compound, and wherein the SIRT1-activating agent is not a stilbene, flavone or flavonoid.
2. The method of claim 1 , wherein the control value is a value that corresponds to the usual cognitive performance of the mammalian subject or is a value of the average cognitive performance of a group of control mammalian subjects of similar age to that of the mammalian subject.
3. The method of claim 1 , wherein the SIRT1-activating agent is administered orally.
4. The method of claim 1 , further comprising administering to the mammalian subject another agent.
5. The method of claim 4 , wherein the other agent is an anti-oxidant.
6. The method of claim 1 , wherein the mammalian subject is a human.