Method and compositions for treatment or prevention of inflammatory conditions
Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and methods include the use of vincamine or a vincamine derivative, either alone or in combination with one or more additional therapeutic agents, including a steroid (preferably a corticosteroid), an angiotensin II receptor (type 1) antagonist, an angiotensin-converting enzyme (ACE) inhibitor, and a non-steroidal anti-inflammatory drug.
1. A method of treating otitis media, the method comprising administering to a patient in need thereof a therapeutically effective amount of (+)-vinpocetine or a salt thereof.
2. The method of claim 1 , further comprising co-administering to the patient a therapeutically effective amount of a corticosteroid.
3. The method of claim 2 , wherein the corticosteroid is triamcinolone, fluocinolone, cortisone, hydrocortisone, ciclesonide, fluticasone, mometasone, betamethasone, deopomedrol, dexamethasone, budesonide, beclomethasone, predisone, methylpredinsolone, predisolone, or a combination thereof.
4. The method of claim 1 , wherein the method comprises administering (+)-vinpocetine or a salt thereof to the patient by middle ear injection or by ear drops.
5. The method of claim 1 , wherein (+)-vinpocetine or a salt thereof is present in a pharmaceutical composition further comprising a pharmaceutically acceptable carrier.
6. The method of claim 1 , wherein (+)-vinpocetine or a salt thereof is administered in an amount of about 0.01 to about 2 mg/kg.
7. The method of claim 1 , wherein (+)-vinpocetine or a salt thereof is administered in an amount of about 0.05 to about 1 mg/kg.
8. The method of claim 1 , wherein (+)-vinpocetine or a salt thereof is administered in an amount of about 0.05 to about 0.5 mg/kg.