Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
1. A compound of a formula
wherein L is selected from a covalent bond and divalent CH═CH, CH 2 CH 2 , OCH 2 CH(OH), O(CH 2 ) 2 O, O(CH 2 ) 3 O, (CH 2 ) 2 NH, (CH 2 ) 2 NHCH 2 , CH 2 CH(CH 2 NH 2 )CH 2 CH 2 , CH 2 CH(CH 2 NH 2 )NHCH 2 and OCH(CH 2 NH 2 )CH 2 O moieties; or a salt thereof.
2. The compound of claim 1 wherein L is a said divalent moiety with a meta-relationship to each said thiophene-2-carboximidamide moiety of said compound.
3. The compound of claim 2 wherein L is selected from divalent O(CH 2 ) 2 O and (CH 2 )NHCH 2 moieties.
4. The compound of claim 1 wherein L is a said divalent moiety with a para-relationship to one of said thiophene-2-carboximidamide moieties.
5. The compound of claim 4 wherein L is a divalent (CH 2 ) 2 NHCH 2 moiety.