IP Library › Granted Patent US 9,248,164
Granted Patent B2
US 9,248,164 · App. 14/117,599 · Granted Feb 2, 2016

Growth factor anchoring type bone graft material, method for producing growth factor anchoring type bone graft material, kit for producing growth factor anchoring type bone graft material, and method for forming bone

Inventors: Kentaro Uchida (Sagamihara, JP); Koji Naruse (Sagamihara, JP); Masashi Takaso (Sagamihara, JP); Takehiko Mima (Sagamihara, JP); Osamu Matsushita (Sagamihara, JP); Takashi Haraguchi (Sagamihara, JP); Nozomu Nishi (Kagawa, JP)
Assignees: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE; NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
A61K38/1825A61K38/1808A61K38/4886A61L27/3608A61L27/54C07K14/33C07K14/485C12N9/52A61L2300/252A61L2300/414A61L2430/02C07K2319/00C07K2319/003C07K2319/70
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Quick Facts
Patent No.
US 9,248,164
App. No.
14/117,599
Granted
Feb 2, 2016
Kind
B2
Abstract

Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

Claims (5)

1. A growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which comprises a growth factor receptor agonist peptide and a collagen-binding peptide,

wherein the bone graft substrate is a high-density collagen material in a sheet form with a collagen fiber density of 100 to 800 mg/cm 3 , and the collagen-binding-site-containing growth factor is formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase.

2. A kit for production of a growth factor anchoring type bone graft material wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which comprises a growth factor receptor agonist peptide and a collagen-binding peptide,

wherein the bone graft substrate is a high-density collagen material in a sheet form with a collagen fiber density of 100 to 800 mg/cm 3 , and the collagen-binding-site-containing growth factor is formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase, which kit comprises: a solution comprising a collagen-binding-site-containing growth factor formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase;

and a bone graft substrate which is said high-density collagen material in a sheet form with the collagen fiber density of 100 to 800 mg/cm 3 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 31, 2013
From: UCHIDA, KENTARO; NARUSE, KOJI; TAKASO, MASASHI; MIMA, TAKEHIKO; MATSUSHITA, OSAMU; HARAGUCHI, TAKASHI; NISHI, NOZOMU
To: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE; NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
Reel/Frame 031863/0203 →
Priority Claims (1)
JP 2011-108650 · May 13, 2011 · national
Continuity (1)
Related Publication 20140335146A1 · Nov 13, 2014