Separation material comprising saccharide ligands

1. A separation material comprising a saccharide-linker-matrix represented by a general formula of

saccharide-linker-matrix, wherein the linker is chosen from the group of linkers consisting of

—X(CH 2 ) s —NH—CO—(CH 2 ) s —CONH—,

—X(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—(CH 2 ) s —CONH—,

—X(CH 2 ) s —NH—CO—CH 2 —(O—C 2 H 4 ) 1 —O—CH 2 —CONH—,

—X(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—CH 2 —(O—C 2 H 4 ) 1 —O—CH 2 —CONH—,

—X(CH 2 ) s —CONH—,

—X(CH 2 ) s —NH—CO—(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—(CH 2 ) s —CONH—,

—X(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—(CH 2 ) s —CONH—,

—X(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—(CH 2 ) s —NH—CH 2 —CH(OH)—,

—X(CH 2 ) s —NH—CO—(CH 2 ) s —NH—CH 2 —CH(OH)—,

—X(CH 2 ) s —CO—NH—(CH 2 ) s —NH—CO—CH(NH 2 )—(CH 2 ) 2 —CO—NH—CH(SH)—CO—NH—CH 2 —CO—NH—CH 2 —CH(OH)—,

wherein

X represents O, N, S or CH 2 ; and

s represents, independently of one another, an integer from 1-10, and

l represents an integer from 1-600.

2. The separation material according to claim 1 wherein the matrix is a synthetic polymer, a peptide or a polysaccharide.

3. The separation material according to claim 1 , wherein the matrix is prepared from hydrophilic and/or hydrophobic synthetic polymers selected from the group consisting of polyethylene (PE), polyoxymethylene (POM), polypropylene (PP), polyvinylchloride (PVC), polyvinyl acetate (PVA), polyvinylidene chloride (PVDC), polystyrene (PS), polytetrafluoroethylene (PTFE), poly-acrylate, poly(methyl methacrylate) (PMMA), polyacrylamide, polyglycidyl methacrylate (PGMA), acrylonitrile butadiene styrene (ABS), polyacrylonitrile (PAN), polyester, polycarbonate, polyethylene terephthalate (PET), polyamide, polyaramide, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polysulfone (PS), polyethersulfone (PES), polyarylethersulfone (PAES), ethylene vinyl acetate (EVA), ethylene vinyl alcohol (EVOH), polyamide-imide, polyaryletherketone (PAEK), polybutadiene (PBD), polybutylene (PB), polybutylene terephthalate (PBT), polycaprolactone (PCL), polyhydroxyalkanoate, polyether ether ketone (PEEK), polyether ketone ketone (PEKK), polyether imide (PEI), polyimide, polylactic acid (PLA), polymethyl pentene (PMP), poly(p-phenylene ether) (PPE), polyurethane (PU), styrene acrylonitrile (SAN), polybutenoic acid, poly(4-allyl-benzoic acid), poly(glycidyl acrylate), polyglycidyl methacrylate (PGMA), poly(allyl glycidyl ether), poly(vinyl glycidyl ether), poly(vinyl glycidyl urethane), polyallylamine, polyvinylamine and copolymers thereof.

4. The separation material according to claim 2 wherein the matrix is prepared from hydrophilic and/or hydrophobic synthetic polymers selected from the group consisting of polyacrylates (PA), poly(methyl methacrylate) (PMMA) or polyglycidyl methacrylate (PGMA), polyvinylpyrrolidone (PVP), polysulfone (PS), polyethersulfone (PES), polyarylethersulfone (PAES) and combinations thereof.

5. The separation material according to claim 2 wherein the matrix has the form of beads, flat sheet membrane or hollow fiber membrane.

6. The separation material according to claim 5 , wherein the matrix has the form of flat sheet membrane or hollow fiber membrane and wherein the flat sheet membrane or hollow fiber membrane is treated with gas plasma before coupling a linker and a saccharide.

7. The separation material according to claim 1 wherein the saccharide is a mono-, di-, tri- or oligosaccharide which is able to bind to another molecule, protein or cell.

8. The separation material according to claim 7 , wherein the saccharide is a blood group A determinant or/and a blood group B determinant.

9. A method for selectively separating substances having the ability to bind to saccharides from a liquid using a separation material according to claim 1 .

10. The method according to claim 9 , wherein the liquid is whole blood or a blood product.