Anti-metastatic agents predicated upon polyamine macrocyclic conjugates
View Patent ↗Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s).
1. A compound represented by the formula:
wherein x=1-6;
wherein y=3 or 4 or 5;
wherein z=3 or 4 or 5;
, or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound comprises structure
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound comprises structure
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4 , wherein the compound comprises compound (47a),
or a pharmaceutically acceptable salt thereof; or compound
(47b), or a pharmaceutically acceptable salt thereof.
6. A compound represented by the formula:
wherein x=0-6;
wherein y=3 or 4 or 5; and
wherein z=3 or 4 or 5;
R=acyl, or alkyl,
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 6 , wherein x=1, y=z=3 and R=acetyl; or x=1, y=z=3 and R=Me.
8. A compound represented by the formula:
wherein x=0-6;
wherein y=2-8;
R=hydrogen, acyl, or alkyl, or a pharmaceutically acceptable salt thereof.
9. The compound of claim 8 , wherein x=1, y=3 and R=acetyl; or x=1, y=3 and R=methyl; or x=1, y=3 and R=ethyl, or a pharmaceutically acceptable salt thereof.