Targeting ABCB5 for cancer therapy
The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
1. A method for treating a subject, comprising
systemically administering an isolated antibody that selectively binds to ABCB5 to a subject having cancer in an effective amount to treat the cancer, wherein the isolated antibody is not co-administered with a chemotherapeutic agent.
2. The method of claim 1 , wherein the isolated antibody is a monoclonal antibody.
3. The method of claim 1 , wherein the isolated antibody has at least one human region.
4. The method of claim 1 , wherein the isolated antibody competitively inhibits binding of mAb 3C2-1D12 to ABCB5.
5. The method of claim 1 , wherein the isolated antibody is of immunoglobulin class IgA, IgGb 1, IgG2, IgG3, IgG4 or IgM.
6. The method of claim 1 , wherein the isolated antibody is a single chain antibody.
7. The method of claim 1 , wherein the subject has melanoma.
8. The method of claim 1 , wherein the subject is a human subject.
9. The method of claim 1 , wherein the subject is a companion animal.
10. The method of claim 1 , wherein the cancer is a cancer having cancer stem cells that express ABCB5 and is selected from the group consisting of biliary tract cancer; brain cancer; breast cancer; cervical cancer; choriocarcinoma; colon cancer; endometrial cancer; esophageal cancer; gastric cancer; intraepithelial neoplasms; lymphomas; liver cancer; lung cancer (e.g. small cell and non-small cell); neuroblastomas; oral cancer; ovarian cancer; pancreas cancer; prostate cancer; rectal cancer; sarcomas; skin cancer; testicular cancer; thyroid cancer; and renal cancer.
11. The method of claim 1 , further comprising, prior to the treatment of the subject detecting the presence of ABCB5 positive stem cells.
12. The method of claim 11 , wherein the presence of ABCB5 positive stem cells is detected by contacting a sample from a subject with a peptide that selectively binds to ABCB5 in order to detect cells that bind to the peptide.
13. The method of claim 12 , wherein the sample is a sample of a tumor mass.