Antibodies against ROR1 and uses thereof

1. An anti-ROR1 antibody comprising a combination of all six CDR regions having the following amino acid sequences:

(a) CDRH1, SEQ ID NO: 57; CDRH2, SEQ ID NO: 58; CDRH3, SEQ ID NO: 59, CDRL1, SEQ ID NO: 60; CDRL2, SEQ ID NO: 61; and CDRL3, SEQ ID NO: 62;

(b) CDRH1, SEQ ID NO: 63; CDRH2, SEQ ID NO: 64; CDRH3, SEQ ID NO: 65, CDRL1, SEQ ID NO: 66; CDRL2, SEQ ID NO: 67; and CDRL3, SEQ ID NO: 68;

(c) CDRH1, SEQ ID NO: 69; CDRH2, SEQ ID NO: 70; CDRH3, SEQ ID NO: 71, CDRL1, SEQ ID NO: 72; CDRL2, SEQ ID NO: 73; and CDRL3, SEQ ID NO: 74;

(d) CDRH1, SEQ ID NO: 75; CDRH2, SEQ ID NO: 76; CDRH3, SEQ ID NO: 77, CDRL1, SEQ ID NO: 78; CDRL2, SEQ ID NO: 79; and CDRL3, SEQ ID NO: 80;

(e) CDRH1, SEQ ID NO: 81; CDRH2, SEQ ID NO: 82; CDRH3, SEQ ID NO: 83, CDRL1, SEQ ID NO: 84; CDRL2, SEQ ID NO: 85; and CDRL3, SEQ ID NO: 86;

(f) CDRH1, SEQ ID NO: 87; CDRH2, SEQ ID NO: 88; CDRH3, SEQ ID NO: 89, CDRL1, SEQ ID NO: 90; CDRL2, SEQ ID NO: 91; and CDRL3, SEQ ID NO: 92;

(g) CDRH1, SEQ ID NO: 93; CDRH2, SEQ ID NO: 94; CDRH3, SEQ ID NO: 95, CDRL1, SEQ ID NO: 96; CDRL2, SEQ ID NO: 97; and CDRL3, SEQ ID NO: 98;

(h) CDRH1, SEQ ID NO: 99; CDRH2, SEQ ID NO: 100; CDRH3, SEQ ID NO: 101, CDRL1, SEQ ID NO: 102; CDRL2, SEQ ID NO: 103; and CDRL3, SEQ ID NO: 104;

(i) CDRH1, SEQ ID NO: 105; CDRH2, SEQ ID NO: 106; CDRH3, SEQ ID NO: 107, CDRL1, SEQ ID NO: 108; CDRL2, SEQ ID NO: 109; and CDRL3, SEQ ID NO: 110;

(j) CDRH1, SEQ ID NO: 111; CDRH2, SEQ ID NO: 112; CDRH3, SEQ ID NO: 113, CDRL1, SEQ ID NO: 114; CDRL2, SEQ ID NO: 115; and CDRL3, SEQ ID NO: 116;

(k) CDRH1, SEQ ID NO: 117; CDRH2, SEQ ID NO: 118; CDRH3, SEQ ID NO: 119, CDRL1, SEQ ID NO: 120; CDRL2, SEQ ID NO: 121; and CDRL3, SEQ ID NO: 122;

(l) CDRH1, SEQ ID NO: 123; CDRH2, SEQ ID NO: 124; CDRH3, SEQ ID NO: 125, CDRL1, SEQ ID NO: 126; CDRL2, SEQ ID NO: 127; and CDRL3, SEQ ID NO: 128; or

(m) CDRH1, SEQ ID NO: 129; CDRH2, SEQ ID NO: 130; CDRH3, SEQ ID NO: 131, CDRL1, SEQ ID NO: 132; CDRL2, SEQ ID NO: 133; and CDRL3, SEQ ID NO: 134.

2. An antibody as claimed in claim 1 comprising the combination of VH and VL region amino acid sequences of:

SEQ ID NO: 5 and SEQ ID NO: 6,

SEQ ID NO: 7 and SEQ ID NO: 8,

SEQ ID NO: 9 and SEQ ID NO: 10,

SEQ ID NO: 11 and SEQ ID NO: 12,

SEQ ID NO: 13 and SEQ ID NO: 14,

SEQ ID NO: 15 and SEQ ID NO: 16,

SEQ ID NO: 17 and SEQ ID NO: 18,

SEQ ID NO: 19 and SEQ ID NO: 20,

SEQ ID NO: 21 and SEQ ID NO: 22,

SEQ ID NO: 23 and SEQ ID NO: 24,

SEQ ID NO: 25 and SEQ ID NO: 26,

SEQ ID NO: 27 and SEQ ID NO: 28, or

SEQ ID NO: 29 and SEQ ID NO: 30, respectively.

3. An antibody as claimed in any of claims 1 to 2 comprising the constant region CH, having the amino acid sequence of SEQ ID NO: 3 and the constant region CL having the amino acid sequence of SEQ ID NO: 4.

4. A pharmaceutical composition comprising an antibody as defined in claim 1 or 2 and a pharmaceutically acceptable excipient, diluent or carrier.

5. A kit of parts comprising:

(i) an antibody as claimed in claim 1 or 2 ;

(ii) apparatus for administering the antibody; and

(iii) instructions for use.

6. A kit of parts comprising:

(i) a pharmaceutical composition as claimed in claim 4 ;

(ii) apparatus for administering the pharmaceutical composition; and

(iii) instructions for use.