Medical devices with an activated coating
View Patent ↗Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.
1. A medical device comprising a polymeric textile having a coating, the coating comprising a natural polymer possessing a functional group having click reactivity selected from the group consisting of thiols, azides, alkynes and alkenes, wherein the coating imparts an activated surface to the textile via the functional group having click reactivity, wherein the natural polymer is selected from the group consisting of chitosan, collagen, hyaluronic acid, polysaccharides and copolymers and combinations thereof.
2. The medical device according to claim 1 , wherein the functional group known to have click reactivity is a thiol.
3. The medical device according to claim 1 , wherein the functional group known to have click reactivity is an azide.
4. The medical device according to claim 1 , wherein the functional group known to have click reactivity is an alkyne.
5. The medical device according to claim 1 , wherein the functional group known to have click reactivity is an alkene.
6. The medical device according to claim 1 , wherein the natural polymer is chitosan.
7. The medical device of claim 1 , wherein the polymeric textile is a surgical mesh.
8. The medical device of claim 1 , wherein the polymeric textile is a sling.
9. The medical device of claim 1 , further comprising a bioactive agent possessing a functional group having click reactivity complementary to the functional group having click reactivity of the coating, wherein the bioactive agent is covalently bonded to the surface of the coated polymeric textile via the activated surface.
10. The medical device of claim 9 , wherein the bioactive agent is selected from the group consisting of anti-adhesives, antimicrobials, analgesics, antipyretics, anesthetics, antiepilutics, antihistamines, anti-intlammatories, cardiovascular drugs, diagnostic agents, synipathominietics, cholinomimetics, anti ics, antispasmodics, muscle relaxants adrenergic neuron Mockers, antineoplastics, immunogenic agents, immunosuppressants, gastrointestinal drugs, diuretics, steroids, lipids, platelet activating drugs, clotting factors chemotherapeutics and combinations thereof.