Processing system for cell cultures and module connecting method of processing system for cell cultures
A processing system for cell cultures for carrying out cell/tissue culturing processes in the field of regenerative medicine, etc. which is a processing system for cell cultures which prevents viruses and human-derived cells, etc. other than a culturing processing target from entering the interior of a closed space from outside of the system to maintain sterility, maintains sealability of the closed spaces of modules, and couples or detaches the plurality of modules in accordance with a wide variety of cell culturing processing steps so that cell culturing processes can be carried out by combining the plurality of culturing processing modules is provided.
1. A processing system for cell cultures comprising:
a plurality of modules that can be mutually connected;
a first closed space provided in each of the modules;
a door that opens/closes an aperture provided in the first closed space;
a sealing tube or silicone seal provided at a peripheral part of the aperture for filling a gap between the door and a module; and
a decontaminating-agent supplying container configured to supply a decontaminating agent, the decontaminating-agent supplying container including one or more supplying pipes that supply the decontaminating agent made into vapor, gas, or mist;
wherein the decontaminating agent is supplied to the first closed space by the decontaminating-agent supplying container;
the decontaminating agent is supplied to a second closed space formed by sealing tubes or silicone seals and the doors of one and the other modules connected to each other, to form an integrated closed space maintaining the plurality of connected modules in a sterile state.
2. The processing system for cell cultures according to claim 1 , further comprising:
module control devices that include circuitry, the module control devices are configured to carry out control so that the modules execute predetermined process in accordance with a command from the module control devices, wherein the module control devices are configured to carry out management of culturing and processing procedures of cells or tissues; and
an integrated control device that includes a CPU, a RAM, and a storage unit, the integrated control device being electrically connected to the circuitry of the module control devices of the modules connected each other via the connecting member and controls operation of the modules; wherein
the integrated control device carries out communication with the plurality of connected modules, recognizes IDs of the modules, and carries out operation commands corresponding to the IDs with respect to the modules so as to associate the plurality of connected modules and subject a series of processing steps of various culturing processes to an integrated process or separately execute the various cell culturing processes, and
wherein the module control devices transmit the measurement results of culturing environments and/or culturing progress to the integrated control device.
3. The processing system for cell cultures according to claim 1 or 2 ,
further comprising a conveyance module, to which the modules are connected, provide with a conveyance robot inside of the conveyance module, the conveyance module including at least one aperture, at least one door, and/or connecting material; wherein
the conveyance robot moves a conveyance object from the first closed space of one of the connected modules to the first closed space of the other module via the second closed space.
4. The processing system for cell cultures according to claim 3 , wherein
the sealing tube or silicone seal has a hollow shape and an injector is configured to inject a gas, etc. into the sealing tube or silicone seal; wherein, the sealing tube or silicone seal is swelled to fill the gap between the door and a module and to hermetically seal the second closed space.
5. A module connecting method of the processing system for cell cultures according to claim 4 , the method comprising:
a step of installing the plurality of modules with a gap therebetween;
a step of swelling sealing tubes or silicone seals provided on the plurality of modules so as to fill the gap and connect the plurality of modules;
a step of supplying the decontaminating agent to the second closed space formed by the plurality of sealing tubes or silicone seals and the plurality of doors from the decontaminating-agent supplying container to decontaminate interior of the second closed space; and
a step of opening the doors to communicate the first closed space and the second closed space with each other and form an integrated sterile closed space.
6. A module connecting method of the processing system for cell cultures according to claim 3 , the method comprising:
a step of connecting each of the plurality of modules respectively via a sealing tube or silicone seal;
a step of supplying the decontaminating agent to the second closed space formed by the plurality of sealing tubes or silicone seals, and the plurality of doors from the decontaminating-agent supplying container to decontaminate interior of the second closed space; and
a step of opening the doors to communicate the first closed space and the second closed space with each other and form an integrated sterile closed space.
7. The processing system for cell cultures according to claim 1 or 2 , wherein
the sealing tube or silicone seal has a hollow shape and an injector is configured to inject a gas, etc. into the sealing tube or silicone seal; wherein, the sealing tube or silicone seal is swelled to fill the gap between the door and a module and to hermetically seal the second closed space.
8. A module connecting method of the processing system for cell cultures according to claim 7 , the method comprising:
a step of connecting each of the plurality of modules respectively via a sealing sealing tube or silicone seal;
a step of supplying the decontaminating agent to the second closed space formed by the plurality of sealing tubes or silicone seals, and the plurality of doors from the decontaminating-agent supplying container to decontaminate interior of the second closed space; and
a step of opening the doors to communicate the first closed space and the second closed space with each other and form an integrated sterile closed space.
9. A module connecting method of the processing system for cell cultures according to claim 7 , the method comprising:
a step of installing the plurality of modules with a gap therebetween;
a step of swelling sealing tubes or silicone seals provided on the plurality of modules so as to fill the gap and connect the plurality of modules;
a step of supplying the decontaminating agent to the second closed space formed by the plurality of sealing tubes or silicone seals and the plurality of doors from the decontaminating-agent supplying container to decontaminate interior of the second closed space; and
a step of opening the doors to communicate the first closed space and the second closed space with each other and form an integrated sterile closed space.
10. A module connecting method of the processing system for cell cultures according to claim 1 or 2 , the method comprising:
a step of connecting each of the plurality of modules respectively via a sealing tube or silicone seal;
a step of supplying the decontaminating agent to the second closed space formed by the plurality of sealing tubes or silicone seals and the plurality of doors from the decontaminating-agent supplying container to decontaminate interior of the second closed space; and
a step of opening the doors to communicate the first closed space and the second closed space with each other and form an integrated sterile closed space.