Radiolabeled compounds and uses thereof
View Patent ↗The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.
1. A compound having the formula:
or a pharmaceutically acceptable salt thereof,
wherein:
r and s are each independently an integer ranging from 0 to 3;
R 1 is —C 1 -C 6 alkyl,
R 2 is —H, and
R 3 is -aryl, -heteroaryl or -napththyl, each of which is substituted with 75 Br, 76 Br, 120 I, 123 I, 124 I, 125 I, 131 I, or —OC 3 HH 2 .
2. The compound of claim 1 , the compound having the formula
or pharmaceutically acceptable salts thereof, wherein Y is —CH— or —N— and R r is —OC 3 HH 2 , 75 Br, 76 Br, 120 I, 123 I, 124 I, 125 I or 131 I.
3. The compound of claim 1 , wherein R 1 is methyl.
4. The compound of claim 1 , having the formula:
or a pharmaceutically acceptable salt thereof, wherein Br is 75 Br or 76 Br and I is 120 I, 123 I, 124 I, 125 I or 131 I.
5. The compound of claim 4 , wherein the compound is
or a pharmaceutically acceptable salt thereof, wherein Br is 75 Br or 76 Br.
6. The compound of claim 4 , wherein the compound is
or a pharmaceutically acceptable salt thereof, wherein I is 120 I, 123 I, 124 I, 125 I or 131 I.
7. The compound of claim 4 , wherein the compound is
or a pharmaceutically acceptable salt thereof, wherein I is 120 I, 123 I, 124 I, 125 I or 131 I.
8. The compound of claim 4 , wherein the compound is
or a pharmaceutically acceptable salt thereof, wherein Br is 75 Br or 76 Br.
9. The compound of claim 4 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
10. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
11. A composition comprising a therapeutically effective amount of a compound of claim 1 or 10 , or a pharmaceutically acceptable salt thereof, and a physiologically acceptable carrier or vehicle.
12. A composition comprising an imaging-effective amount of a compound of claim 1 or 10 , or a pharmaceutically acceptable salt thereof, and a physiologically acceptable carrier or vehicle.
13. A composition comprising a physiologically acceptable salt and the compound of claim 1 or 10 , or a pharmaceutically acceptable salt thereof.