Methods for lowering blood glucose
In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
1. A method of lowering blood glucose in an animal comprising administering to the animal a composition comprising from 25 to 500 mg of ursolic acid, and a compound having a structure represented by a formula:
wherein each ----- represents a covalent bond selected from a single or double bond;
wherein each of R 21a , R 21b , R 21c , R 21d , R 21e , R 22 , R 23a , R 23b , R 23c and R 23d in said formula is chosen independently from H and OH or a stereoisomer, tautomer, solvate, or pharmaceutically acceptable salt thereof;
thereby lowering the blood glucose in the animal.
2. A method of lowering blood glucose in an animal comprising administering to the animal a composition comprising from 25 to 500 mg of ursolic acid, and a compound of formula: