Treatment of cancers with A-8R peptide
The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
1. A method to treat a patient with hormone-refractory prostate cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient.
2. A method to treat a patient with metastatic prostate cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient.
3. A method to treat a patient with late stage prostate cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient.
4. A method to treat a patient with an sCGa1-expressing pancreatic cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient.
5. A method to treat a patient with an sCGa1-expressing gastrointestinal cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient.
6. A method to treat a patient with an sCGa1-expressing cancer in need of such treatment, comprising administering an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO:1 to the patient,
wherein the cancer is selected from the group consisting of: neuroblastoma; lung cancer; bile duct cancer; non small cell lung carcinoma; hepatocellular carcinoma; nasopharyngeal carcinoma; gastric cancer; colon cancer; uterine cervical carcinoma; gall bladder cancer; prostate cancer; breast cancer; testicular germ cell tumors; colorectal cancer; glioma; thyroid cancer; basal cell carcinoma; gastrointestinal stromal cancer; hepatoblastoma; endometrial cancer; ovarian cancer; and urothelial cancer.