Methods and compositions for modulating T cell and/or B cell activation
The present invention provides methods of reducing or enhancing T cell activation and/or B cell activation in a subject, comprising administering to a subject an effective amount of an inhibitor or enhancer, respectively, of Semaphorin 6D (Sema6D) activity on T cells and/or B cells.
1. A fusion protein comprising the amino acid sequence of SEQ ID NO:2.
2. A nucleic acid molecule comprising a nucleotide sequence encoding the fusion protein of claim 1 .
3. A nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1.
4. A composition comprising the fusion protein of claim 1 in a pharmaceutically acceptable carrier.
5. A composition comprising the nucleic acid molecule of claim 2 in a pharmaceutically acceptable carrier.
6. A composition comprising the nucleic acid molecule of claim 3 in a pharmaceutically acceptable carrier.