Liquid pharmaceutical formulations of palonosetron

1. A pharmaceutical single-use, unit-dose formulation for intravenous administration to a human to reduce the likelihood of cancer chemotherapy-induced nausea and vomiting, comprising a 50 mL sterile isotonic solution buffered at a pH of 4.8±0.5 comprising:

palonosetron hydrochloride in an amount of 0.75 mg based on the weight of its free base;

450.0 mg sodium chloride;

2.5 mg EDTA;

18.5 mg sodium citrate; and

7.8 mg citric acid monohydrate,

wherein said formulation is contained in a polyethylene multilayer film infusion bag comprising an isoprene rubber stopper.