Disposable device for centrifugal blood separation
A continuous centrifugal blood separation device has a simple and reliable structure. The continuous blood centrifugal device includes an RBC (red blood cell) collector that is coaxial with a supernatant collector. The continuous blood centrifugal device includes an axial symmetric barrier disposed between the RBC collector and the supernatant collector in order to avoid turbulence that can otherwise be caused by the supernatant collector.
1. A disposable continuous blood centrifugal device comprising:
a rotatable housing;
a rotatable inner bowl disposed within the rotatable housing and defining a space between the rotatable inner bowl and the rotatable housing, the space sized to permit blood to separate into layers, with a more dense layer closest to the rotatable housing and a less dense layer closest to the rotatable inner bowl;
a first collector configured to collect blood components from within the more dense layer;
a second collector configured to collect blood components from within the less dense layer;
a rotatable barrier disposed within the rotatable housing above the rotatable inner bowl, the rotatable barrier configured to direct blood components within the more dense layer towards the first collector and to direct blood components within the less dense layer towards the second collector; and
a stationary structure extending downwardly through the rotatable housing and the rotatable inner bowl, the stationary structure including a blood inlet, a first outlet in fluid communication with the first collector and a second outlet in fluid communication with the second collector,
wherein the blood inlet extends to a position near a bottom of the rotatable housing, and the stationary structure further comprises a saline inlet that extends to a position near the bottom of the rotatable housing.
2. The continuous blood centrifugal device of claim 1 , wherein a first collection chamber in which the first collector is disposed is formed between the rotatable barrier and a top of the rotatable housing.
3. The continuous blood centrifugal device of claim 1 , wherein a second collection chamber in which the second collector is disposed is formed within the rotatable barrier or between the rotatable barrier and the rotatable inner bowl.
4. The continuous blood centrifugal device of claim 1 , wherein the rotatable housing comprises a frustoconical shape.
5. The continuous blood centrifugal device of claim 4 , wherein the rotatable inner bowl comprises a tapered outer surface.
6. The continuous blood centrifugal device of claim 5 , wherein the tapered outer surface is configured to provide a non-uniform size of the space defined between the inner rotatable bowl and the outer housing.
7. The continuous blood centrifugal device of claim 1 , wherein the rotatable housing comprises a cylindrical shape.
8. The continuous blood centrifugal device of claim 7 , wherein the rotatable inner bowl comprises a cylindrical outer surface.
9. The continuous blood centrifugal device of claim 8 , wherein the cylindrical outer surface is configured to provide a uniform annular shape of the space defined between the inner rotatable bowl and the outer housing.
10. The continuous blood centrifugal device of claim 1 , wherein the rotatable barrier includes a disk portion that extends between the first collector and the second collector in order to reduce turbulence that could otherwise cause remixing of the blood components within the more dense layer with the blood components within the less dense layer.
11. The continuous blood centrifugal device of claim 1 , wherein the bottom of the rotatable housing includes a bump out to accommodate a saline supply that is in fluid communication with the saline inlet.
12. The continuous blood centrifugal device of claim 1 , further including a deflector having a periphery that is sized to force saline to flow through a red blood cell layer disposed closest to the inner surface of the rotatable housing.
13. The continuous blood centrifugal device of claim 12 , wherein, when in use, saline exiting a saline supply channel passes underneath the deflector.