Hepcidin mimetic peptides and uses thereof
Compounds and methods are described herein that can be used to treat subjects for conditions related to hepcidin activity, such as but not limited diseases of iron metabolism, beta thalassemia, hemochromatosis, iron-loading anemias, alcoholic liver disease, or chronic hepatitis C.
1. A compound, or pharmaceutically acceptable salt thereof, of formula
wherein R 1 is —S—CH 3 or H.
2. The compound, or pharmaceutically acceptable salt thereof, of claim 1 , wherein R 1 is —S—CH 3 .
3. The compound, or pharmaceutically acceptable salt thereof, of claim 1 , wherein R 1 is H.
4. A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of formula
wherein R 1 is —S—CH 3 or H.
5. The pharmaceutical composition of claim 4 further comprising a pharmaceutically acceptable excipient.
6. The pharmaceutical composition of claim 4 , wherein R 1 is —S—CH 3 .
7. The pharmaceutical composition of claim 4 , wherein R 1 is H.
8. A method of reducing serum iron concentration in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a compound, or pharmaceutically acceptable thereof, of formula
wherein R 1 is —S—CH 3 or H.
9. The method of claim 8 , wherein R 1 is —S—CH 3 .
10. The method of claim 8 , wherein R 1 is H.
11. A method of therapeutic treatment for beta thalassemia comprising administering to a subject in need thereof a pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of formula
wherein R 1 is —S—CH 3 or H.
12. The method of claim 11 , wherein R 1 is —S—CH 3 .
13. The method of claim 11 , wherein R 1 is H.