Organ preservation system
View Patent ↗An organ preservation system having an organ chamber with a perfusate reservoir surrounded by a heat exchanger. The system has a pump for circulating perfusate, which draws perfusate from the reservoir and passes the perfusate through a bubble trap, and temperature and pressure sensors prior to entering the chamber where the organ is perfused. An oxygenator with a platform and a filter is situated within the perfusate reservoir such that perfusate leaving the organ which rests on the platform passes through the filter before dripping into the perfusate reservoir below. The pump re-circulates perfusate from the perfusate reservoir. The oxygenator has gas permeable tubes wound around support legs of the oxygenator. Circulation of oxygen through the tubes allows for gas exchange by diffusion across the membrane to oxygenate perfusate flowing around the tubes.
1. A tissue or organ preservation system for circulating perfusate in contact with a tissue or organ, comprising: an organ chamber for containing an organ or tissue; a perfusate circuit comprising a perfusate pump; a perfusate reservoir at the base of the organ chamber for collecting perfusate exiting an organ or flowing past tissue, said perfusate reservoir in communication with the perfusion circuit; a support platform located within the organ chamber and located above the perfusate reservoir for supporting the organ or tissue; a heat exchanger locating a heat exchanger fluid in contact with at least one surface of the perfusate reservoir; an oxygenator mechanism disposed within the perfusate reservoir and configured to oxygenate the perfusate within the perfusate reservoir, the oxygenator mechanism comprises an elongated flexible gas conduit located below the support platform, a conduit wall of the conduit is an oxygen diffusion membrane through which oxygen is transferred to the perfusate adjacent the conduit within the perfusate reservoir, the conduit is arranged in an at least partially non-linear and overlapping configuration, the oxygenator mechanism is distinct from the perfusate pump; a perfusate stirring element disposed within the perfusate reservoir; and, a temperature equilibrating and oxygen enhancing perfusate stirring element disposed within the perfusate reservoir, and, a stirring drive motor configured to rotate the perfusate stirring member in one direction about an axis of rotation, wherein the elongated flexible gas conduit is gas permeable tubing, wherein the at least partially non-linear and overlapping configuration is a wound configuration, and wherein the spacing of the tubing is maintained by comb-like slots in the tubing supports.
2. A tissue or organ preservation system for circulating perfusate in contact with a tissue or organ, comprising: an organ chamber for containing an organ or tissue; a perfusate circuit comprising a perfusate pump; a perfusate reservoir at the base of the organ chamber for collecting perfusate exiting an organ or flowing past tissue, said perfusate reservoir in communication with the perfusion circuit; a support platform located within the organ chamber and located above the perfusate reservoir for supporting the organ or tissue; a heat exchanger locating a heat exchanger fluid in contact with at least one surface of the perfusate reservoir; an oxygenator mechanism disposed within the perfusate reservoir and configured to oxygenate the perfusate within the perfusate reservoir, the oxygenator mechanism comprises an elongated flexible gas conduit located below the support platform, a conduit wall of the conduit is an oxygen diffusion membrane through which oxygen is transferred to the perfusate adjacent the conduit within the perfusate reservoir, the conduit is arranged in an at least partially non-linear and overlapping configuration the oxygenator mechanism is distinct from the perfusate pump; a perfusate stirring element disposed within the perfusate reservoir; and, a temperature equilibrating and oxygen enhancing perfusate stirring element disposed within the perfusate reservoir, and, a stirring drive motor configured to rotate the perfusate stirring member in one direction about an axis of rotation, wherein support member comprises support legs extending into the perfusate reservoir; and wherein the elongated flexible gas conduit, gas permeable tubing for transporting oxygen from an oxygen supply source to the perfusate reservoir, the tubing is wound around the support legs within the perfusate reservoir; wherein the tubing spacing is maintained by comb-like slots in the support legs.