Mucoadhesive patch with opposite ratios of nonionic and anionic hydrocolloids in adhesive and backing layer
A mucoadhesive patch that consists of an adhesive layer and a backing layer, wherein the adhesive layer contains a nonionic and an anionic hydrocolloid in a weight ratio of 1:2 to 1:5, and the backing layer contains a matrix of a nonionic and an anionic hydrocolloid in a weight ratio of 2:1 to 5:1.
1. A patch for the administration of active substances to body orifices or body parts with a mucosal lining of the epidermis, which consists of an adhesive layer and a backing layer, with the backing layer containing a matrix of a nonionic and an anionic hydrocolloid in a weight ratio of 2:1 to 5:1, and with the adhesive layer containing a nonionic and an anionic hydrocolloid in the opposite weight ratio of 1:2 to 1:5.
2. A patch in accordance with claim 1 , wherein the backing layer is a matrix of a nonionic and an anionic hydrocolloid in a ratio of 3:1, while the adhesive layer is a matrix of a nonionic and an anionic hydrocolloid in the opposite ratio of 1:3.
3. A patch in accordance with claim 1 , wherein the nonionic hydrocolloid is a hydroxypropylmethyl cellulose or ethyl cellulose.
4. A patch in accordance with claim 1 , wherein the nonionic hydrocolloid is selected from the group consisting of guar gum, carob bean flour, polyvinyl pyrrolidone, and starch.
5. A patch in accordance with claim 1 , wherein the anionic hydrocolloid is carbomer (polyacrylic acid) or gum arabic (salt of arabic acid).
6. A patch in accordance with claim 1 , wherein the anionic hydrocolloid is selected from the group consisting of agar, alginic acid, carboxymethyl cellulose, carrageenin, gelatin type B, karaya gum, pectin, tragacanth, and polymethylvinyl ether/maleic anhydride.
7. A patch in accordance with claim 1 , wherein the weight ratio of the nonionic and anionic hydrocolloids in the total patch is 1:1 to 1:5.
8. A patch in accordance with claim 1 , wherein the weight ratio of the nonionic and anionic hydrocolloids in the total patch is 1:1 to 1:2.
9. A patch in accordance with claim 1 , wherein the adhesive layer and the backing layer are inseparably joined, which is accomplished by means of the aforementioned proportions of the nonionic and anionic polymers.
10. A patch in accordance with claim 1 , wherein the active substances are selected from the group consisting of antiseptics, antimycotics, virostatics, antibiotics, local anesthetics, corticoids, and vitamins.
11. A patch in accordance with claim 1 , wherein the active substances are aqueous and/or alcoholic extracts of plants selected from the group consisting of Echinacea, Sambucus, Matricaria, Thymus, Camiphora, Salix, Camelia, Salvia, Melissa, Myrtillum; and Allium.
12. A patch in accordance with claim 1 , wherein flavorings, sweeteners, coloring agents, stabilizers, antioxidants, preservatives, surface-active substances; or fillers are added both in the adhesive layer and the backing layer.