Methods of treating thyroid eye disease
The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount that is effective to inhibit hyaluronan synthesis in a retro-ocular space. The pharmaceutical compositions hat includes a carrier suitable for ophthalmic delivery and an agent that interferes with hyaluronan synthesis. Combination therapies are also disclosed.
1. A method of treating thyroid eye disease consisting of:
administering to a patient having thyroid eye disease one or more DP1 antagonists in an amount that is effective to inhibit hyaluronan synthesis in a retro-ocular space, wherein said administering is carried out by injecting the one or more DP1 antagonists into the retro-ocular space or applying a composition containing the one or more DP1 antagonists onto a surface of the patient's eye, wherein the DP1 antagonist is from the group consisting of laropiprant, 2-[(1R)-9-(4-chlorobenzyl)-8-((R)-methylsulfinyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid, and 2-[(1R)-9-(4-chlorobenzyl)-8-((S)-methylsulfinyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid.
2. The method according to claim 1 , wherein the one or more DP1 antagonist is present in a pharmaceutical composition further comprising a carrier selected from the group of a liquid, suspension, polymeric delivery vehicle, mucoadhesive substance, or nanosphere.