Azole compounds as PIM inhibitors

1. A compound of Formula IIa

wherein R is optionally substituted thiadiazolyl or optionally substituted oxadiazolyl;

wherein R 1 is C 3-6 cycloalkylcarbonylamino, optionally substituted 6-membered heterocyclylcarbonylamino, optionally substituted phenyl or optionally substituted 5-membered heterocyclyl, optionally substituted 6-membered heterocyclyl, optionally substituted 9 membered heterocyclyl or optionally substituted 10 membered heterocyclyl; and

wherein R 2 is H or halo;

provided R is not 2-[4-(1-piperdinyl)butylamino]-1,3,4-oxadiazolyl, when R 1 is phenyl, and R 2 is H;

and a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein R 1 is unsubstituted or substituted phenyl, unsubstituted or substituted biphenyl, unsubstituted or substituted pyrazinyl, unsubstituted or substituted pyridyl, unsubstituted or substituted pyrimidinyl, unsubstituted or substituted pyridazinyl, unsubstituted or substituted quinolyl, unsubstituted or substituted dihydrobenzofuryl, unsubstituted or substituted quinoxalinyl, unsubstituted or substituted indazolyl, unsubstituted or substituted 6,7-dihydro-5H-pyrrolo[2,3-b]pyrazinyl, unsubstituted or substituted triazolyl, unsubstituted or substituted dihydro-2H-pyranyl, unsubstituted or substituted thiazolyl, unsubstituted or substituted pyrazolyl, or unsubstituted or substituted thienyl and a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein R is oxadiazolyl optionally substituted with amino, C 1-6 alkylamino, C 1-6 haloalkylamino, cyano-C 1-6 alkylamino, amino-C 1-6 alkylamino, hydroxy, C 1-6 alkoxy, halo, C 1-6 alkyl, C 3-6 cycloalkyl, optionally substituted phenyl, aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulphonyl, C 1-6 alkylthio, C 3-6 cycloalkylamino, optionally substituted 4-6-membered nitrogen containing heterocyclyl substituted amino, optionally substituted 4-6-membered nitrogen containing heterocyclyl-C 1-4 alkylamino, optionally substituted 9-10-membered nitrogen containing heterocyclyl substituted amino, optionally substituted 9-10-membered nitrogen containing heterocyclyl-C 1-4 alkylamino, optionally substituted phenylamino, optionally substituted phenyl-C 1-4 alkylamino, optionally substituted 4-6 membered nitrogen containing heterocyclyl, or optionally substituted 4-6-membered oxygen containing heterocyclylamino; and a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein R is thiadiazolyl optionally substituted with amino, C 1-6 alkylamino, C 1-6 haloalkylamino, cyano-C 1-6 alkylamino, amino-C 1-6 alkylamino, hydroxy, C 1-6 alkoxy, halo, C 1-6 alkyl, C 3-6 cycloalkyl, optionally substituted phenyl, aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulphonyl, C 1-6 alkylthio, C 3-6 cycloalkylamino, optionally substituted 4-6-membered nitrogen containing heterocyclyl substituted amino, optionally substituted 4-6-membered nitrogen containing heterocyclyl-C 1-4 alkylamino, optionally substituted 9-10-membered nitrogen containing heterocyclyl substituted amino, optionally substituted 9-10-membered nitrogen containing heterocyclyl-C 1-4 alkylamino, optionally substituted phenylamino, optionally substituted phenyl-C 1-4 alkylamino, optionally substituted 4-6 membered nitrogen containing heterocyclyl, or optionally substituted 4-6-membered oxygen containing heterocyclylamino; and a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein R is

wherein R F is H, amino, methylamino, propylamino, isopropylamino, tert-butylamino, cyanomethylamino, aminopropylamino, 1,1,1-trifluoroethylamino, methylcarbonylamino, hydroxy, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, hexyloxy, methylthio, bromo, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isoamyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, aminocarbonyl, cyclopropylamino, piperidylamino, piperidylmethylamino, piperidylethylamino, indolylmethylamino, 2,3-dimethylaminoindolymethylamino, phenylamino, 3-fluorophenylamino, benzylamino, 3-(methylcarbonylamino)benzylamino, 3-(methylamino)benzylamino, 3-(methoxymethylcarbonylamino)benzylamino, 4-(methylcarbonylamino)benzylamino, 2-methyl-2-phenylethylamino, phenyl, pyrrolidinyl, 3-amino-1-pyrrolidinyl, piperidyl, 4-amino-1-piperidyl, pyrazolyl, morpholinyl, 2-methylmorpholinyl, 3-methylmorpholinyl, 3,3-dimethylmorpholinyl, 3-ethylmorpholinyl, piperazinyl, oxetanyl, or azetidinyl; and a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein R 1 is optionally substituted phenyl or optionally substituted biphenyl; and a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein R 1 is optionally substituted pyrazinyl, optionally substituted pyridyl, or optionally substituted pyrimidinyl, or optionally substituted pyridazinyl; and a pharmaceutically acceptable salt thereof.

8. The compound of claim 1 , wherein R 1 is optionally substituted quinolyl, optionally substituted dihydrobenzofuryl, optionally substituted quinoxalinyl, optionally substituted indazolyl, or optionally substituted 6,7-dihydro-5H-pyrrolo[2,3-b]pyrazinyl; and a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 , wherein R 1 is unsubstituted or substituted triazolyl, unsubstituted or substituted dihydro-2H-pyranyl, unsubstituted or substituted thiazolyl, unsubstituted or substituted pyrazolyl, or unsubstituted or substituted thienyl; and a pharmaceutically acceptable salt thereof.

10. The compound of claim 1 , wherein R 1 is

pyrimidinyl unsubstituted or substituted with one or more amino, halo, cyano, hydroxy, oxo, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkylamino, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)amino, phenylamino, C 3-6 cycloalkyl-C 1-3 -alkylamino, C 3-6 cycloalkylamino, carboxy, aminocarbonyl, C 1-6 alkylaminocarbonyl, C 3-6 cycloalkylaminocarbonyl, phenylaminocarbonyl, optionally substituted 5-6-membered nitrogen containing heterocyclyl)carbonyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-6 cycloalkoxy, optionally substituted phenyloxy, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)oxy, optionally substituted phenyl, optionally substituted 6-membered nitrogen containing heterocyclyl, optionally substituted 5-membered nitrogen containing heterocyclyl, optionally substituted 9-10-membered nitrogen containing heterocyclyl, or C 3-6 cycloalkyl,

pyrazinyl unsubstituted or substituted with one or more amino, halo, cyano, hydroxy, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkylamino, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)amino, phenylamino, C 3-6 cycloalkyl-C 1-3 -alkylamino, C 3-6 cycloalkylamino, carboxy, aminocarbonyl, phenylaminocarbonyl, C 3-6 cycloalkylaminocarbonyl, optionally substituted 5-6-membered nitrogen containing heterocyclyl)carbonyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-6 cycloalkoxy, optionally substituted phenyloxy, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)oxy, optionally substituted phenyl, optionally substituted 6-membered nitrogen containing heterocyclyl, optionally substituted 5-membered nitrogen containing heterocyclyl, optionally substituted 9-10-membered nitrogen containing heterocyclyl, or C 3-6 cycloalkyl,

pyridinyl unsubstituted or substituted with one or more amino, halo, cyano, hydroxy, oxo, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkylamino, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)amino, phenylamino, C 3-6 cycloalkyl-C 1-3 -alkylamino, C 3-6 cycloalkylamino, carboxy, aminocarbonyl, C 1-6 alkylaminocarbonyl, C 3-6 cycloalkylaminocarbonyl, phenylaminocarbonyl, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)carbonyl, C 1-6 alkylsulfonyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-6 cycloalkoxy, optionally substituted phenyloxy, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)oxy, optionally substituted phenyl, optionally substituted 6-membered nitrogen containing heterocyclyl, optionally substituted 5-membered nitrogen containing heterocyclyl, optionally substituted 9-10-membered nitrogen containing heterocyclyl, or C 3-6 cycloalkyl,

phenyl unsubstituted or substituted with one or more amino, halo, cyano, hydroxy, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkylamino, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)amino, phenylamino, C 3-6 cycloalkyl-C 1-3 -alkylamino, C 3-6 cycloalkylamino, carboxy, aminocarbonyl, C 1-6 alkylaminocarbonyl, phenylaminocarbonyl, optionally substituted 5-6-membered nitrogen containing heterocyclyl)carbonyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-6 cycloalkoxy, optionally substituted phenyloxy, (optionally substituted 5-6-membered nitrogen containing heterocyclyl)oxy, optionally substituted phenyl, optionally substituted 6-membered nitrogen containing heterocyclyl, optionally substituted 5-membered nitrogen containing heterocyclyl, optionally substituted 9-10-membered nitrogen containing heterocyclyl, or C 3-6 cycloalkyl,

3-quinolinyl, 1H-indazolyl, 2,2-dimethyl-2,3-dihydro-1-benzofuranyl, 6-quinoxalinyl, 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-b]pyrazinyl,

thiazolyl unsubstituted or substituted with aminocarbonyl, C 3-6 cycloalkylaminocarbonyl, 4-methyl-1H-imidazolyl, 2-oxo-pyridinyl, furyl, or methylpiperidinyl,

triazolyl unsubstituted or substituted with C 3-6 cyclopropyl,

dihydro-2H-pyranyl,

pyrazolyl unsubstituted or substituted with 2-methylpropyl, or 2-(4-morpholinyl)ethyl, or

thiophenyl unsubstituted or substituted with thienyl;

and a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein R 1 is

2-pyrimidinyl, 4-methyl-2-pyrimidinyl, 4-ethyl-5-fluoro-6-methyl-2-pyrimidinyl, 4-methoxy-5-fluoro-6-methyl-2-pyrimidinyl, 4-amino-6-methyl-2-pyrimidinyl, 4-isopropyl-2-pyrimidinyl, 4-trifluoromethyl-6-pyrimidinyl, 4-trifluoromethyl-2-pyrimidinyl, 4-trifluoromethoxy-2-pyrimidinyl, 4-(1-methylethylamino)-2-pyrimidinyl, 2-isopropylamino-4-pyrimidinyl, 4-(1-methyl-3-piperidinyl)amino-2-pyrimidinyl, 4-methoxy-2-pyrimidinyl, 2-methoxy-4-pyrimidinyl, 4-isopropoxy-2-pyrimidinyl, 2,4-dimethoxy-6-pyrimidinyl, 6-methoxy-2-(1-methylethoxy)-4-pyrimidinyl, 5-fluoro-4-methoxy-2-pyrimidinyl, 4-ethoxy-5-fluoro-2-pyrimidinyl, 5-fluoro-4-methoxy-2-pyrimidinyl, 4-phenyloxy-2-pyrimidinyl, 4-(1-methyl-3-piperidinyl)oxy-2-pyrimidinyl, 4-phenylamino-2-pyrimidinyl, 4-cyclopropyl-2-pyrimidinyl, 4-carboxy-6-cyclopropyl-2-pyrimidinyl, 5-aminocarbonyl-4-cyclopropyl-2-pyrimidinyl, 4-aminocarbonyl-2-pyrimidinyl, 4-methylaminocarbonyl-2-pyrimidinyl, 4-cyclopropylaminocarbonyl-2-pyrimidinyl, 2-(4-morpholinyl)-4-pyrimidinyl, 4-(4-morpholinyl)-2-pyrimidinyl, 4-(3-methyl-4-morpholinyl)-2-pyrimidinyl, 4-(1-piperidinyl)-2-pyrimidinyl, 4-(2-methyl-1-piperidinyl)-2-pyrimidinyl, 4-(1-methyl-3-piperidinyl)-2-pyrimidinyl, 4-(3-methyl-1-piperidinyl)-2-pyrimidinyl, 4-(3-amino-1-piperidinyl)-2-pyrimidinyl, 4-(3-dimethyl-amino-1-piperidinyl)-2-pyrimidinyl, 4-(3-hydroxy-1-piperidinyl)-2-pyrimidinyl, 4-(2-methyl-1-pyrrolidinyl)-2-pyrimidinyl, 4-(2-methoxymethyl-1-pyrrolidinyl)-2-pyrimidinyl, 4-(2-methoxy-1-pyrrolidinyl)-2-pyrimidinyl, 4-(4-methyl-1-piperazinyl)-2-pyrimidinyl, 4-(4-methyl-3-oxo-1-piperazinyl)-2-pyrimidinyl, 4-(3-amino-piperidinyl)-2-pyrimidinyl, 4-(1-methyl-3-piperidinyl)oxy-2-pyrimidinyl, 4-cyclopropyl-2-pyrimidinyl, 2-cyclopropyl-4-pyrimidinyl, 5-fluoro-4-cyclopropyl-2-pyrimidinyl, 4-(2-chlorophenyl)-2-pyrimidinyl, 4-(2-fluorophenyl)-2-pyrimidinyl, 4-(2-methylphenyl)-2-pyrimidinyl, 4-phenyl-2-pyrimidinyl, 2-isopropylamino-4-oxo-6-pyrimidinyl, 2-cyclopropyl-4-oxo-6-pyrimidinyl, 2-methoxy-4-oxo-6-pyrimidinyl, 2-cyclopropyl-4-oxo-6-pyrimidinyl,

2-pyrazinyl, 6-amino-2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-methyl-2-pyrazinyl, 6-cyclopropylmethyl-amino-2-pyrazinyl, 6-(1-methylethylamino)-2-pyrazinyl, 5-(N-ethyl-N-methyl-amino)-2-pyrazinyl, 2-(N,N-dimethylamino)-6-pyrazinyl, 6-(N,N-diethylamino)-2-pyrazinyl, 6-cyclopropyl-amino-2-pyrazinyl, 6-cyclopentylamino-2-pyrazinyl, 6-cyclohexylamino-2-pyrazinyl, 5-ethoxy-2-pyrazinyl, 2-isopropoxy-6-pyrazinyl, 6-(2,2,2-trifluoro-1-methylethoxy)-2-pyrazinyl, 6-methoxy-2-pyrazinyl, 6-ethoxy-2-pyrazinyl, 5-(1-methylethoxy)-2-pyrazinyl, 6-(1-methylethoxy)-2-pyrazinyl, 5-butoxy-2-pyrazinyl, 6-(cyclopentyloxy)-2-pyrazinyl, 5-(cyclopentyloxy)-2-pyrazinyl, 6-(phenyloxy)-2-pyrazinyl, 6-(3-piperidinyloxy)-2-pyrazinyl, 5-(1-pyrrolidinyl)-2-pyrazinyl, 6-(1-pyrrolidinyl)-2-pyrazinyl, 5-(2-oxo-1-pyrrolidinyl)-2-pyrazinyl, 6-(3,3-difluoro-1-pyrrolidinyl)-2-pyrazinyl, 4-(1-methyl-2-oxo-piperazinyl)-2-pyrazinyl, 5-(4-methyl-1-piperazinyl)-2-pyrazinyl, 6-(1-piperidinyl)-2-pyrazinyl, 6-(2-methyl-1-piperidinyl)-2-pyrazinyl, 6-(4,4-difluoro-1-piperidinyl)-2-pyrazinyl, 6-(4-methyl-1-piperidinyl)-2-pyrazinyl, 6-(4-morpholinyl)-2-pyrazinyl, 5-(4-morpholinyl)-2-pyrazinyl, 6-(1-methyl-1H-pyrazol-4-yl)-2-pyrazinyl, 5-(3-methyl-1H-pyrazol-1-yl)-2-pyrazinyl, 6-cyclopropyl-2-pyrazinyl, 6-phenyl-2-pyrazinyl, 6-(4-fluorophenyl)-2-pyrazinyl, 6-(3-fluorophenyl)-2-pyrazinyl, 6-(2-fluorophenyl)-2-pyrazinyl, 6-(3-chlorophenyl)-2-pyrazinyl, 6-(2-chlorophenyl)-2-pyrazinyl, 6-(4-chlorophenyl)-2-pyrazinyl,

2-pyridinyl, 4-pyridinyl, 3-pyridinyl, 2-amino-4-pyridinyl, 6-amino-2-pyridinyl, 5-amino-4-pyridinyl, 6-(1-methylethyl-amino)-2-pyridinyl, 6-(cyclopropylmethylamino)-2-pyridinyl, 6-cyclopentylamino-2-pyridinyl, 6-(cyclohexylamino)-2-pyridinyl, 6-trifluoromethyl-2-pyridinyl, 5-fluoro-6-methyl-2-pyridinyl, 6-fluoro-2-pyridinyl, 6-cyano-2-pyridinyl, 6-hydroxy-2-pyridinyl, 3-methylsulphonyl-6-pyridinyl, 5,6-dimethoxy-2-pyridinyl, 5-methoxy-3-pyridinyl, 6-ethoxy-2-pyridinyl, 6-propoxy-2-pyridinyl, 2-(1-methylethoxy)-6-pyridinyl, 6-(cyclobutyloxy)-2-pyridinyl, 6-(cyclopentyloxy)-2-pyridinyl, 6-(cyclohexyloxy)-2-pyridinyl, 3-aminocarbonylpyridin-6-yl, 2-methylaminocarbonylpyridin-6-yl, 3-methylaminocarbonylpyridin-6-yl, 3-(N,N-dimethylamino)carbonylpyridin-5-yl, 2-(N,N-dimethylamino)carbonylpyridin-6-yl, 3-methylaminocarbonylpyridin-5-yl, 3-isopropylaminocarbonylpyridin-5-yl, 2-isopropylaminocarbonylpyridin-6-yl, 3-cyclopropylaminocarbonylpyridin-5-yl, 2-cyclopropylaminocarbonylpyridin-6-yl, 5-(4-morpholinylcarbonyl)-3-pyridinyl, 3-(4-morpholinylcarbonyl)-6-pyridinyl, 6-(1-pyrrolidinyl)-2-pyridinyl, 6-(2-oxo-1-pyrrolidinyl)-2-pyridinyl, 6-(4-methyl-1-piperazinyl)-2-pyridinyl, 4-(1-methyl-2-oxo-piperazinyl)-2-pyridinyl, 6-(4-morpholinyl)-2-pyridinyl, 6-(1-piperidinyl)-2-pyridinyl, 6-(3-methylpiperidin-1-yl)pyridin-2-yl, 6-(4-methyl-1-piperidinyl)-2-pyridinyl, 6-(2-methylpiperidin-1-yl)pyridin-2-yl, 6-(3-amino-piperidinyl)-2-pyridinyl, 6-(2-oxo-1-piperidinyl)-2-pyridinyl, 6-(2-methyl-1H-imidazol-1-yl)-2-pyridinyl, 6-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl, 6-(1H-pyrazol-1-yl)-2-pyridinyl, 6-(3-methyl-1H-pyrazol-1-yl)-2-pyridinyl, 6-(2-oxo-1-pyridinyl)-2-pyridinyl, 6-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-pyridinyl, 6-phenyl-2-pyridinyl, 6-(4-chlorophenyl)-2-pyridinyl,

phenyl, 2-fluorophenyl, 2,3-difluorophenyl, 2,4-difluorophenyl, 2,6-difluorophenyl, 2-fluoro-5-(1-methylethoxy)phenyl, 3-(1-methylethoxy)phenyl, 3-fluoro-5-(1-methylethoxy)phenyl, 2-fluoro-5-(N-phenyl-aminocarbonyl)phenyl, 2-fluoro-5-(N, N-dimethyl-aminocarbonyl)phenyl, 2-fluoro-5-(N-methylaminocarbonyl)phenyl, 4-aminocarbonyl-2-fluorophenyl, 3-aminophenyl, 3-(trifluoromethyl)phenyl, 3-(trifluoromethoxy)phenyl, 3-methoxyphenyl,

3-quinolinyl, 3-biphenyl, 1H-indazol-6-yl, 2,2-dimethyl-2,3-dihydro-1-benzofuran-6-yl, 6-quinoxalinyl, 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-b]pyrazin-2-yl,

5-aminocarbonyl-1,3-thiazol-2-yl, 4-cyclopropylaminocarbonyl-1,3-thiazol-2-yl, 5-cyclopropylaminocarbonyl-1,3-thiazol-2-yl, 2-(4-methyl-1H-imidazol-1-yl)-1,3-thiazol-4-yl, 2-(2-oxo-1-pyridinyl)-1,3-thiazol-4-yl, 2-(3-furyl)-1,3-thiazol-4-yl, 2-(2-methylpiperidin-1-yl)thiazol-4-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1-(2-methylpropyl)-1H-pyrazol-4-yl, 1-(2-(4-morpholinyl)ethyl)-1H-pyrazol-4-yl, 3-cyclopropyl-1H-1,2,4-triazol-5-yl, 3,6-dihydro-2H-pyran-4-yl or 2,2′-bi-thiophen-5-yl;

and a pharmaceutically acceptable salt thereof.

12. The compound of claim 1 , wherein R 2 is H or fluoro; and a pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein R 1 is cyclopropylcarbonylamino, cyclobutylcarbonylamino, pyrmindinylcarbonylamino, or pyridylcarbonylamino; and a pharmaceutically acceptable salt thereof.

14. A compound selected from

5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-N-(2,2,2-trifluoroethyl)-1,3,4-oxadiazol-2-amine;

5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

6-cyclopropyl-2-(5-(5-((1-methylethyl)amino)-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-4-pyrimidinecarboxamide;

5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-N-(1-methylethyl)-1,3,4-oxadiazol-2-amine;

((5-(3-(4-(1-methylethyl)-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-yl)amino)acetonitrile;

5-(3-(6-cyclopropyl-2-pyrazinyl)-1H-indol-5-yl)-N-(1-methylethyl)-1,3,4-oxadiazol-2-amine;

N-tert-butyl-5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

N-cyclopropyl-5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

5-(3-(4-cyclopropyl-2-pyrimidinyl)-6-fluoro-1H-indol-5-yl)-N-(1-methylethyl)-1,3,4-oxadiazol-2-amine;

5-(3-(6-cyclopropyl-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

5-(3-(2-cyclopropyl-4-pyrimidinyl)-1H-indol-5-yl)-N-(1-methylethyl)-1,3,4-oxadiazol-2-amine;

5-(3-(6-(1-methylethoxy)-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

2-(5-(5-(tert-butylamino)-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-4-pyrimidinecarboxamide;

4-cyclopropyl-2-(5-(5-((1-methylethyl)amino)-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-5-pyrimidinecarboxamide;

5-(3-(4-(2-methyl-1-piperidinyl)-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

5-(3-(4-(2-methyl-1-pyrrolidinyl)-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

6-(5-(5-amino-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-N-cyclopentyl-2-pyrazinamine;

5-(3-(6-(4,4-difluoro-1-piperidinyl)-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

5-(3-(6-(2-methyl-1-piperidinyl)-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

5-(3-(6-(3,3-difluoro-1-pyrrolidinyl)-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;

6-(5-(5-amino-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-N-(cyclopropylmethyl)-2-pyrazinamine;

5-(3-(4-cyclopropyl-2-pyrimidinyl)-1H-indol-5-yl)-N-3-oxetanyl-1,3,4-oxadiazol-2-amine;

6-(5-(5-amino-1,3,4-oxadiazol-2-yl)-1H-indol-3-yl)-N-(1-methyl ethyl)-2-pyrazinamine;

5-(3-(6-(1-piperidinyl)-2-pyrazinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine; and

5-(3-(4-phenyl-2-pyrimidinyl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine; or a pharmaceutically acceptable salt thereof.

15. A composition comprising a therapeutically effective amount of the compound of claim 1 , or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.

16. A composition comprising a therapeutically effective amount of the compound of claim 14 , or the pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.