Nutritive compositions and methods of using same
The invention provides intradialytic parenteral nutrition (IDPN) solutions with low carbohydrate for the treatment of malnutrition in dialysis patients. The IDPN solutions of the invention are particularly advantageous for the treatment of malnutrition in patients who are diabetic or suffer from other glucose management related pathologies or patients who require strict fluid management.
1. A method, comprising parenterally administering a sterile aqueous intradialytic parenteral nutrition (IDPN) solution to a patient in need thereof, the IDPN solution consisting essentially of between 0.05 and 0.07 g/mL of dextrose and between 0.12 and 0.18 g/mL of amino acids, wherein the solution is lipid-free and the dextrose and the amino acids are both dissolved in the same aqueous solution.
2. The method of claim 1 , wherein the amino acids include combinations of two or more of the standard 20 amino acids.
3. The method of claim 1 , wherein the solution consists essentially of between 0.055 and 0.065 g/mL of dextrose and between 0.12 and 0.18 g/mL of amino acids.
4. The method of claim 1 , wherein the solution consists essentially of between 0.05 and 0.07 g/mL of dextrose and between 0.15 and 0.17 g/mL of amino acids.
5. The method of claim 1 , wherein the solution consists essentially of between 0.055 and 0.065 g/mL of dextrose and between 0.15 and 0.17 g/mL of amino acids.
6. The method of claim 1 , wherein the solution is free of vitamin B1.
7. The method of claim 1 , wherein the solution is free of minerals.
8. The method of claim 4 , wherein the solution is free of vitamin B1.
9. The method of claim 1 , wherein the amino acids include all 20 of the standard amino acids.
10. The method of claim 1 , wherein the amino acids include 17 of the standard amino acids.
11. The method of claim 1 , wherein the solution has a volume between 100 mL and 2 L.
12. The method of claim 1 , wherein the solution has a volume between 350 mL and 635 L.
13. The method of claim 1 , wherein the solution is packaged in a sterile container.
14. The method of claim 1 , wherein the solution does not induce hyperglycemia in the patient.
15. The method of claim 1 , wherein the solution does not induce rhonchi edema in the patient.
16. The method of claim 1 , wherein the solution does not induce dyspnea in the patient.
17. The method of claim 1 , wherein the solution does not increase the respiratory rate of the patient.
18. The method of claim 1 , wherein the solution does not induce hypertension in the patient.
19. The method of claim 1 , wherein the solution does not induce anxiety in the patient.
20. The method of claim 1 , wherein the patient is a hemodialysis patient.
21. The method of claim 3 , wherein the patient is a hemodialysis patient.
22. The method of claim 4 , wherein the patient is a hemodialysis patient.
23. The method of claim 5 , wherein the patient is a hemodialysis patient.
24. The method of any one of claims 20 - 23 , wherein the hemodialysis patient is diabetic.
25. The method of claim 24 , further comprising administering insulin to the patient.
26. The method of claim 24 , further comprising monitoring glucose tolerance in the patient.
27. The method of any one of claims 20 - 23 , further comprising monitoring protein status in the patient.
28. The method of claim 27 , wherein the patient is diabetic.
29. A method, comprising parenterally administering a sterile aqueous intradialyic parenteral nutrition (IDPN) solution to a patient in need thereof, the IDPN solution comprising between 0.05 and 0.07 g/mL of dextrose and between 0.12 and 0.18 g/mL of amino acids, wherein the solution is lipid-free and the dextrose and the amino acids are dissolved in the same aqueous solution.
30. The method of claim 29 , wherein the solution comprises between 0.055 and 0.065 g/mL of dextrose and between 0.12 and 0.18 g/mL of amino acids.
31. The method of claim 29 , wherein the solution comprises between 0.05 and 0.07 g/mL of dextrose and between 0.15 and 0.17 g/mL of amino acids.
32. The method of claim 29 , wherein the solution comprises between 0.055 and 0.065 g/mL of dextrose and between 0.15 and 0.17 g/mL of amino acids.
33. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not induce hyperglycemia in the patient.
34. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not induce rhonchi edema in the patient.
35. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not induce dyspnea in the patient.
36. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not increase the respiratory rate of the patient.
37. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not induce hypertension in the patient.
38. The method of claim 29 , wherein the solution, when administered to a patient in need thereof, does not induce anxiety in the patient.
39. The method of claim 29 , wherein the patient is a hemodialysis patient.
40. The method of claim 39 , wherein the hemodialysis patient is diabetic.
41. The method of claim 40 , further comprising administering insulin to the patient.
42. The method of claim 40 , further comprising monitoring glucose tolerance in the patient.
43. The method of any one of claims 39 - 41 , further comprising monitoring protein statue in the patient.