Particle-containing membrane and particulate electrode for analyte sensors
Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
1. A system for continuous in vivo measurement of an analyte in a host, the system comprising:
a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte concentration; and
a layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising a metal, wherein the particle-containing domain is configured to react with at least one interfering species.
2. The system of claim 1 , wherein the particle-containing domain is more distal to the sensor than other domains of the layer.
3. The system of claim 1 , wherein the particle-containing domain comprises at least one material selected from the group consisting of platinum, platinum-iridium, iridium, palladium, graphite, gold, silver, silver chloride, carbon, and conductive polymers.
4. The system of claim 1 , wherein the metal comprises sputtered metal.
5. The system of claim 4 , wherein the sputtered metal is platinum.
6. The system of claim 1 , wherein the particle-containing domain comprises a conductive particles concentration that is sufficient for the particle-containing domain to function as a conductive film.
7. The system of claim 1 , wherein the particle-containing domain is configured to reduce flux therethrough of hydrogen peroxide.
8. The system of claim 1 , wherein the particle-containing domain is non-powered.
9. The system of claim 1 , wherein the particle-containing domain is powered.
10. The system of claim 9 , wherein the sensor electronics are configured to apply a potential to the particle-containing domain.
11. The system of claim 1 , wherein the layer comprises an analyte-permeable polymer.
12. The system of claim 11 , wherein the analyte-permeable polymer comprises a hydrophilic polymer.
13. The system of claim 11 , wherein the analyte-permeable polymer comprises at least one of polyurethane or silicone.
14. The system of claim 1 , wherein the interfering species interferes with measurement of the analyte concentration to produce a signal that does not accurately represent the analyte concentration.
15. The system of claim 1 , wherein the interfering species is a reactive metabolic species.
16. The system of claim 1 , wherein the interfering species is a reactive oxygen species.
17. The system of claim 1 , wherein the interfering species is a reactive nitrogen species.
18. The system of claim 1 , wherein the interfering species is H 2 O 2 .