IP Library › Granted Patent US 9,339,531
Granted Patent B2
US 9,339,531 · App. 13/203,402 · Granted May 17, 2016

Recognition of CYP2E1 epitopes

Inventor: Dolores Benedicta Njoku (Baltimore, MD)
Assignee: The Johns Hopkins University
A61K39/0008C12N9/0077G01N33/564C12N2770/24211G01N2333/80G01N2800/08G01N2800/50
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Quick Facts
Patent No.
US 9,339,531
App. No.
13/203,402
Granted
May 17, 2016
Kind
B2
Abstract

A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune disease.

Claims (4)

1. An isolated cDNA which encodes a purified CYP2E1 epitope comprising the sequence of SEQ ID NO: 2, wherein the epitope is 21-30 amino acids in length.

2. An isolated cDNA having at least 90% sequence identity to the isolated cDNA of claim 1 .

3. The isolated cDNA of claim 2 , wherein the isolated cDNA has at least 95% sequence identity to the isolated cDNA of claim 1 .

4. The isolated cDNA of claim 2 , wherein the isolated cDNA has at least 99% sequence identity to the isolated cDNA of claim 1 .

Assignments (1)
CONFIRMATORY LICENSE Recorded Dec 11, 2017
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044824/0995 →
Continuity (2)
Provisional Application 61155673 · Feb 26, 2009
Related Publication 20120040377A1 · Feb 16, 2012