Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1)
The present invention includes compositions and methods for targeting the LOX-1 receptor on immune cells and uses for the anti-LOX-1 antibodies.
1. A LOX-1-specific antibody linked to one or more antigens; wherein the antibody comprises the variable regions of SEQ ID NOS:7 and 8.
2. The antibody of claim 1 , wherein the antibody is in a fusion protein with one half of a cohesin-dockerin binding pair.
3. The antibody of claim 2 , further comprising a complementary half of the cohesin-dockerin binding pair that is a fusion protein with an antigen.
4. The antibody of claim 1 , wherein the antibody comprises the heavy and light chain of SEQ ID NOS:7 and 8.
5. The antibody of claim 1 , wherein the antigen is a viral antigen, bacterial antigen, fungal antigen, protozoal antigen, parasitic antigen, tumor antigen or antigen involved in autoimmune disease or allergy and graft rejection.
6. The antibody of claim 1 , wherein the antibody is humanized.
7. The antibody of claim 1 , wherein the antigen is a human immunodeficiency virus (HIV) antigen.
8. The antibody of claim 7 , wherein the HIV antigen is a gene product of the gag gene, a gene product of the pol gene, a gene product of the env gene, the Nef protein, or reverse transcriptase.
9. A LOX-1-specific antibody linked to one or more antigens; wherein the antibody comprises all the antigen combining regions of SEQ ID NOS:7 and 8.
10. The antibody of claim 9 , wherein the antigen is a viral antigen, bacterial antigen, fungal antigen, protozoal antigen, parasitic antigen, tumor antigen or antigen involved in autoimmune disease or allergy and graft rejection.
11. The antibody of claim 9 , wherein the antibody is humanized.
12. The antibody of claim 9 , wherein the antigen is a human immunodeficiency virus (HIV) antigen.
13. The antibody of claim 12 , wherein the HIV antigen is a gene product of the gag gene, a gene product of the pol gene, a gene product of the env gene, the Nef protein, or reverse transcriptase.