Stem cell factor inhibitor
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.
1. An anti-stem cell factor antibody that specifically binds to stem cell factor isoform b relative to stem cell factor isoform a or an antigen-binding antibody fragment that specifically binds to stem cell factor isoform b relative to stem cell factor isoform a.
2. The anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 wherein the antibody or the antigen-binding antibody fragment specifically binds to a protein comprising an amino acid sequence provided by SEQ ID NO: 4 or antibody-binding fragment thereof.
3. The anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 wherein the antibody is a monoclonal antibody or the antigen-binding antibody fragment is a fragment of a monoclonal antibody.
4. The anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 wherein the antibody is a polyclonal antibody.
5. The anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 wherein the antibody is a humanized antibody or the antigen-binding antibody fragment is a fragment of a humanized antibody.
6. The anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 wherein the antibody or antigen-binding antibody fragment is a Fab, a Fab′, a F(ab′), a Fv fragment, a scFv fragment, or a linear antibody.
7. A composition comprising the anti-stem cell factor antibody or the antigen-binding antibody fragment of claim 1 .
8. The composition of claim 7 further comprising a stem cell factor isoform b polypeptide.
9. The composition of claim 8 wherein the antibody or antigen-binding antibody fragment is bound to the stem cell factor isoform b polypeptide.
10. The composition of claim 7 comprising a physiologically appropriate solution for administration to a subject.
11. The composition of claim 10 formulated for administration into an airway of a subject.