Modulators of Plexin B2 activity
Disclosed herein are novel compositions and methods for the inhibition of Plexin B2-mediated Angiogenin activity. Such compositions and methods are useful, for example, for the treatment of cancer, the treatment of wet AMD and the inhibition of angiogenesis. Also disclosed herein are methods of determining whether a test agent is a modulator of Plexin B2 activity.
1. An isolated antibody or antigen binding fragment thereof that specifically binds to an Angiogenin (ANG) binding epitope of Plexin B2, wherein the ANG binding epitope consisting of an amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3.
2. The antibody or antigen binding fragment thereof of claim 1 , wherein the antibody or antigen binding fragment thereof inhibits the binding of Angiogenin to Plexin B2.