Bacterial anti-phage defense systems
An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.
1. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 3001, thereby killing the microbe.
2. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NON: 2773, thereby killing the microbe.
3. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2774, thereby killing the microbe.
4. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2775, thereby killing the microbe.
5. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2776, thereby killing the microbe.
6. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2777, thereby killing the microbe.
7. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2778, thereby killing the microbe.
8. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2779, thereby killing the microbe.
9. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2780, thereby killing the microbe.
10. A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin as set forth in SEQ ID NO: 2781, thereby killing the microbe.