Pyrrolopyridineamino derivatives as MPS1 inhibitors

1. A compound of formula I

wherein:

R 1 is hydrogen, (1-5C)alkyl, (1-5C)fluoroalkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)alkyl, aryl, aryl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, —S(O) 2 —R a , —C(O)—R a , or —C(O)—O—R a , wherein R a is (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)alkyl, aryl, aryl-(1-4C)alkyl, heteroaryl or heteroaryl-(1-4C)alkyl, and wherein any (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)alkyl, aryl, aryl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl group present in a R 1 substituent group is optionally substituted by methyl, trifluoromethyl, methoxy, trifluoromethoxy, halo, cyano, nitro, hydroxy, mercapto, amino, carboxy, carbamoyl, or sulphamoyl;

R 2 is an aryl, aryl(1-2C)alkyl, 5- or 6-membered heteroaryl or a 5- or 6-membered heteroaryl(1 -2C)alkyl,

wherein R 2 is optionally substituted by one or more substituents selected from halogeno, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, mercapto, amino, carboxy, carbamoyl, sulphamoyl,

or a group of the formula:

L-L 0 -R b

wherein

L is absent or a linker group of the formula —[CR g R h ] n — in which n is an integer selected from 1, 2, 3 or 4, and R g and R h are each independently selected from hydrogen or (1-2C)alkyl;

L 0 is absent or is selected from O, S, SO, SO 2 , N(R c ), C(O), C(O)O, OC(O), CH(OR c ),)C(O)N(R c ), N(R c )C(O), N(R c )C(O)N(R d ), SO 2 N(R c ), or N(R c )SO 2 , wherein R c and R d are each independently selected from hydrogen or (1-2C)alkyl; and

R b is (1-4C)alkyl, aryl, aryl-(1-4C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1 -4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;

and wherein R b is optionally further substituted by one or more substituents independently selected from oxo, halogeno, cyano, nitro, hydroxy, NR e R f , (1-5C)alkyl, (1-5C)alkoxy, (1-5C)alkanoyl, (1-5C)sulphonyl or aryl; and wherein R e and R f are each independently selected from hydrogen or (1-4C)alkyl or (3-6C)cycloalkyl-(1-4C)alkyl; or R e and R f can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-7 membered heterocyclic, heteroaryl or carbocyclic ring;

R 3 is H, (1-3C)alkyl, halogeno or CF 3 ;

R 4 is cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)perfluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR i R j , or S(O) 2 NR i R j ; wherein R i and R j are each independently selected from H or (1-3C)alkyl;

X is CH or CR 5 ;

W, Y and Z are each independently selected from N, CH, or CR 5 ;

R 5 is halogeno, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, mercapto, amino, carboxy, carbamoyl, sulphamoyl, ureido, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl,

or R 5 is a group of the formula:

-L 1 -L 2 -R 7

wherein

L 1 is absent or a linker group of the formula —[CR 8 R 9 ] n — in which n is an integer selected from 1, 2, 3 or 4, and R 8 and R 9 are each independently selected from hydrogen or (1-2C)alkyl;

L 2 is absent or is selected from O, S, SO, SO 2 , N(R 10 ), C(O), C(O)O, OC(O), CH(OR 10 ), C(O)N(R 10 ), N(R 10 )C(O), N(R 10 )C(O)N(R 11 ), S(O) 2 N(R 10 ), or N(R 13 )SO 2 , wherein R 10 and R 11 are each independently selected from hydrogen or (1-2C)alkyl; and

R 7 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1 -6C)alkyl, heteroaryl, heteroaryl-(1 -6C)alkyl, heterocyclyl, heterocyclyl-(1 -6C)alkyl,

and wherein R 7 is optionally further substituted by one or more substituents independently selected from hydrogen, oxo, halogeno, cyano, nitro, hydroxy, NR 12 R 13 , (1-4C)alkoxy, (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-5C)alkyl, aryl, aryl-(1-5C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, heterocyclyl, heterocyclyl-(1 -5C)alkyl, heteroaryl, heteroaryl-(1-5C)alkyl, CONR 12 R 13 and SO 2 NR 12 R 13 ;

R 12 and R 13 are each independently selected from hydrogen or (1-2C)alkyl; or R 12 and R 13 can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-7 membered heterocyclic or heteroaryl ring;

or either W and Z, W and Y or Z and X are both CR 5 and the R 5 groups on the adjacent carbon atoms are linked such that, together with the carbon atoms to which they are attached, they form a fused 4-7 membered heterocyclic, heteroaryl or carbocyclic ring;

or a pharmaceutically acceptable salt or solvate thereof.

2. A compound according to claim 1 , wherein R 1 is hydrogen, (1-5C)alkyl, (1-5C)fluoroalkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)alkyl, aryl, aryl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, —S(O) 2 —R a , —C(O)—R a , or —C(O)—O—R a , wherein R a is (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-2C)alkyl, aryl, aryl-(1-2C)alkyl, heteroaryl or heteroaryl-(1-2C)alkyl, and wherein any (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(12C)alkyl, aryl, aryl-(1-2C)alkyl, heteroaryl, heteroaryl-(1-2C)alkyl group present in a R 1 substituent group is optionally substituted by methyl, trifluoromethyl, methoxy, trifluoromethoxy, halo, cyano, hydroxy or amino.

3. A compound according to claim 1 , wherein R 1 is hydrogen or —C(O)—O—R a , wherein R a is (1-5C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-2C)alkyl, and wherein any (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-2C)alkyl group is optionally substituted by methyl, trifluoromethyl, methoxy, trifluoromethoxy, halo, cyano, hydroxy or amino.

4. A compound according to claim 1 , wherein R 1 is hydrogen or —C(O)—O—R a , wherein R a is (1-5C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-2C)alkyl.

5. A compound according to claim 1 , wherein R 2 is an aryl or a 5- or 6-membered heteroaryl, wherein R 2 is optionally substituted by one or more substituents selected from trifluoromethyl, cyano, amino, or a group of the formula:

L-L 0 -R b

wherein

L is absent or a linker group of the formula —[CR g R h ] n — in which n is 1 or 2, and R g and R h are hydrogen;

L 0 is absent or is selected from O, SO 2 , N(R c ), C(O)O, C(O)N(R c ), or SO 2 N(R c ), wherein R c is selected from hydrogen or (1-2C)alkyl; and

R b is (1-4C)alkyl, heteroaryl, or heterocyclyl-(1-4C)alkyl;

and wherein R b is optionally further substituted by one or more substituents independently selected from oxo, and NR e R f ; and wherein R e and R f can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-7 membered heterocyclic ring.

6. A compound according to claim 5 , wherein R 2 is a 5-membered heteroaryl having one of the following structures:

wherein R 14 is H, methyl or trifluoromethyl.

7. A compound according to claim 1 , wherein R 3 is H or chloro.

8. A compound according to claim 7 , wherein R 3 is H.

9. A compound according to claim 1 , wherein R 4 is cyano, (1-3C)alkyl, (1-3C)perfluoroalkyl, (1-3C)alkoxy, (1-3C)perfluoroalkoxy or halo.

10. A compound according to claim 9 , wherein R 4 is chloro of methoxy.

11. A compound according to claim 1 , wherein X is CH, and W, Y or Z are selected from N, CH or CR 5 , with the proviso that one of W, Y and Z is CR 5 .

12. A compound according to claim 1 , wherein R 5 is halogeno, trifluoromethyl, cyano, hydroxy, or R 5 is a group of formula:

-L 1 -L 2 -R 7

wherein

L 1 is absent or a linker group of the formula —[CR 8 R 9 ] n — in which n is 1, and R 8 and R 9 are each independently selected from hydrogen or (1-2C)alkyl;

L 2 is absent or is selected from O, SO 2 , N(R 10 ), C(O), C(O)N(R 10 ), N(R 10 )C(O), or S(O) 2 N(R 10 ), or N(R 13 )SO 2 , wherein R 10 is selected from hydrogen or (1-2C)alkyl; and

R 7 is (1-6C)alkyl, aryl, heteroaryl, heteroaryl-(1-6C)alkyl, heterocyclyl, or heterocyclyl-(1-6C)alkyl, wherein R 7 is optionally further substituted by one or more substituents independently selected from oxo, halogeno, cyano, NR 12 R 13 , (1-4C)alkoxy, (1-5C)alkyl, or (1-5C)alkanoyl; and

wherein R 12 , and R 13 are each independently selected from hydrogen or (1-2C)alkyl; or

R 12 and R 13 can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-7 membered heterocyclic ring.

13. A compound according to claim 12 , wherein R 5 is selected from one of the following structures:

wherein R 6 is independently selected from the group including hydrogen, (1-5C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-5C)alkyl, aryl, aryl-(1-5C)alkyl, (1-5C)alkanoyl, (1-5C)sulphonyl.

14. A compound selected from any one of the following:

isopropyl 6-((4-methoxy-2-(1-methyl-1H-pyrazol-4-yl)pyrimidin-5-yl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-((4-(1,2-dimethyl-1H-imidazol-5-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(4-(1,3-dimethyl-1H-pyrazol-4-yl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-((2-chloro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenyl)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-((2-chloro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenyl)-1-(2-methoxyethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(1,4-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenyl)-1-(cyclopropylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 6-((2-chloro-4-(3,3-difluoroazetidine-1-carbonyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-chloro-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)phenyl)(3 ,3-difluoroazetidin-1-yl)methanone;

propyl-6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

ethyl-6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

methyl-6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(oxazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(thiazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(5-methylisoxazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-chloro-4-(pyrazin-2-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

cyclobutyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

cyclopentyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(6-methylpyridin-3-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-imidazol-2-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1,3-dimethyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1,5-dimethyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(pyridin-3-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-chloro-4-(pyrimidin-5-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-chloro-4-(6-methoxypyridin-3-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

cyclobutyl-6-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

cyclobutyl-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl)-1-cyclopentyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

isopropyl 6-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

cyclopentyl 6-((2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((4-(azetidine-1-carbonyl)-2-chlorophenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(1,2-dimethyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1-(5-methylpyridin-2-yl)-1H-pyrrolo [3,2-c]pyridin-6-ylamino)benzamide;

3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1-(pyrimidin-2-yl)-1H-pyrrolo [3,2-c]pyridin-6-ylamino)benzamide;

3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1-(pyridin-2-yl)-1H-pyrrolo [3,2-c]pyridin-6-ylamino)benzamide;

N-(2-chloro-4-(2-methoxypyridin-4-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(2-methoxypyridin-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(2,4-dimethylthiazol-5-yl)phenyl)-2(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(2,4-dimethylthiazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1-methyl-1H-pyrazol-5-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-pyrazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

isopropyl 6-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

N-(2-chloro-4-(1-methyl-1H-pyrazol-3-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(4-(dimethylamino)piperidin-1-yl)methanone;

tert-butyl-6-(2-chloro-4-(4-(dimethylamino)piperidine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

cyclopentyl 6-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(4-methoxypiperidin-1-yl)methanone;

tert-butyl 6-(2-chloro-4-(4-methoxypiperidine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-pyrazol-3-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone;

tert-butyl 6-(2-chloro-4-(4-methylpiperazine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-chloro-4-(3-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(S,S-dioxo-thiomorpholino)methanone;

(3-chloro-4-(3-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(3-methoxyazetidin-1-yl)methanone;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(pyrrolidin-1-yl)methanone;

tert-butyl 6-(2-chloro-4-(pyrrolidine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-N-ethyl-N-methyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

tert-butyl 6-(2-chloro-4-(ethyl(methyl)carbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(S,S-dioxo-thiomorpholino)methanone;

tert-butyl 6-(2-chloro-4-(S,S-dioxo-thiomorpholine-4-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-chlorophenyl)-1-(cyclohexylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

3-chloro-N-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

3-chloro-N-(2-chlorophenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chlorophenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chlorophenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

(3-chloro-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(3-methoxyazetidin-1-yl)methanone;

tert-butyl 6-(2-chloro-4-(3-methoxyazetidine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chlorophenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-4-(1-isopropyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(1-cyclopentyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(3-chloro-1-(cyclopentylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(3-chloro-1-(cyclopropylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3,5-dichloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

tert-butyl 6-(4-(dimethylcarbamoyl)-2-(trifluoromethoxy)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2,6-dichloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-4-(1-(cyclopropylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

cyclopentyl 6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-4-(1-(cyclohexylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(1-(cyclopentylsulfonyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

3-chloro-4-(3-chloro-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

tert-butyl 6-(2-methoxyphenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-N,N-dimethyl-4-((2-(1-methyl-1H-pyrazol-4-yl)-1((5-methylisoxazol-3-yl)methyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)benzamide;

(3-methoxy-4-(2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(3-methoxyazetidin-1-yl)methanone;

tert-butyl 6-(2-methoxy-4-(3-methoxyazetidine-1-carbonyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-N,N-dimethyl-4-(2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

tert-butyl 6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(oxazol-5-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

3-chloro-N-(2-chloro-4-(methylsulfonyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

2-(3-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenoxy)acetonitrile;

tert-butyl 6-(3-(cyanomethoxy)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-4-(1-(cyclopentylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

N-(4-(aminomethyl)-2-methoxyphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-((dimethylamino)methyl)-2-methoxyphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(4-((dimethylamino)methyl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-methoxy-4-((methylamino)methyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-methoxy-4-(pyrrolidin-1-ylmethyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

tert-butyl 6-(2-methoxy-4-(pyrrolidin-1-ylmethyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-cyanophenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-chloro-4-(methylsulfonyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

(3-methoxy-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(3-methoxyazetidin-1-yl)methanone;

3-methoxy-N-(2-methoxyethyl)-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

(3-methoxy-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(morpholino)methanone;

tert-butyl 6-(2-methoxy-4-(3-methoxyazetidine-1-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxy-4-(2-methoxyethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxy-4-(morpholine-4-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

N-(2-methoxyphenyl)-2-(oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-acetylphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzenesulfonamide;

tert-butyl 6-(2-chloro-4-(N,N-dimethylsulfamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-chloro-4-(2-oxopyrrolidin-1-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

2-(4-(6-(2,4-dimethoxyphenylamino)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide;

3-chloro-4-(3-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

N-(2-methoxy-4-(thiomorpholinomethyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine-S,S-dioxide;

(3-methoxy-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)(thiomorpholino)methanone-S,S-dioxide;

N-(2-chloro-4-(methylsulfonyl)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

4-methoxy-N,N-dimethyl-3-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-3-(trifluoromethoxy)benzamide

3-chloro-N-methyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

3-methoxy-N-methyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

N-(2-fluoro-4-methoxyphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxy-4-(trifluoromethyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chloro-4-(difluoromethoxy)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxypyridin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-fluoro-2-methoxyphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxyphenyl)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chloro-4-(methylsulfonyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-( 1-methylpiperidin-4-yl)benzamide;

N-(2-chloro-4-fluorophenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chloro-4-(1H-1,2,4-triazol-1-yl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

2-(1-(difluoromethyl)-1H-pyrazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

3-methoxy-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide;

N-(2,4-dimethoxyphenyl)-2-(1((5-methylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

1-(4-(4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)phenyl)piperazin-1-yl)ethanone;

N-(4-(morpholinomethyl)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-(2-methoxyethoxy)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-((1H-pyrazol-1-yl)methyl)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-(2-morpholinoethoxy)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(1H-pyrazol-4-yl)-N-(4-(thiomorpholinomethyl)phenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine-S,S-dioxide;

4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzonitrile;

N-(3 ,4-dimethoxyphenyl)-1-methyl-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxyphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzenesulfonamide;

N-(2-ethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide;

2-(1H-pyrazol-4-yl)-N-(2-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-chloro-4-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2,4-dimethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridin-6-amine;

N-(4-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(5-fluoropyridin-2-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(p-tolylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

2-(1H-pyrazol-4-yl)-N-(4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(4-fluorophenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(3 ,4-dimethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

tert-butyl-6-(2-chloro-4-(2-oxopyrrolidin-1-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxy-4-(thiomorpholinomethyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate-S,S-dioxide;

tert-butyl 6-(2-methoxy-4-(thiomorpholine-4-carbonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate-S,S-dioxide;

tert-butyl-6-(2-chloro-4-(methylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-methoxy-4-(methylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-fluoro-4-methoxyphenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((2-methoxy-4-(trifluoromethyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-chloro-4-(difluoromethoxy)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxypyridin-3-ylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-((4-fluoro-2-methoxyphenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxyphenylamino)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-chloro-4-(methylsulfonyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 6-(2-methoxy-4-(1-methylpiperidin-4-ylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-chloro-4-fluorophenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

tert-butyl-6-(2-chloro-4-(1H-1,2,4-triazol-1-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;

tert-butyl 2-(1-(difluoromethyl)-1H-pyrazol-4-yl)-6-(2-methoxyphenylamino)-1H-pyrrolo [3,2-c]pyridine-1-carboxylate;

or a pharmaceutically acceptable salt or solvate thereof.

15. A pharmaceutical composition comprising (a) a compound, or a pharmaceutically acceptable salt or solvate thereof, as defined in claim 1 , and (b) a pharmaceutically acceptable diluent or carrier.

16. A method of treating a proliferative disorder in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound of formula I

wherein:

R 1 , R 2 , R 3 , W, X, Y, and Z is are as defined in claim 1 and

R 4 is H, cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)perfluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR i R j , or S(O) 2 NR i R j ; wherein R i and R j are each independently selected from H or (1-3C)alkyl;

or a pharmaceutically acceptable salt or solvate thereof.

17. The method of claim 16 , wherein the proliferative disorder is a cancer.

18. A method of synthesizing a compound of the formula I, or a pharmaceutically acceptable salt or solvate thereof, as claimed in claim 1 , the method comprising:

a) reacting an intermediate of formula A:

wherein R 1 , R 2 , and R 3 each have any one of the meanings as defined in claim 1 , and LG A is a suitable leaving group;

with an intermediate of formula B:

wherein R 4 , X, Z, W, and Y have any one of the definitions set out in claim 1 ; and

b) optionally thereafter, and if necessary:

i) removing any protecting groups present;

ii) converting the compound formula I into another compound of formula I; and/or

iii) forming a pharmaceutically acceptable salt or solvate thereof.