IP Library Granted Patent US 9,375,451
Granted Patent B2
US 9,375,451 · App. 14/444,278 · Granted Jun 28, 2016

Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore

Inventors: Jacqueline M. Hibbert (Stockbridge, GA); Jonathan K. Stiles (Powder Springs, GA); Kayellen Umeakunne (Pittsburgh, PA); Hyacinth I. Hyacinth (Stockbridge, GA)
Assignee: NUTRIGLOBAL, INC.
A61K33/32A23L1/293A23L1/3002A23L1/302A23L1/303A23L1/304A23L1/3051A61K31/015A61K31/07A61K31/198A61K31/355A61K31/375A61K31/4172A61K31/455A61K31/51A61K31/525A61K31/59A61K31/675A61K31/714A61K33/00A61K33/06A61K33/18A61K33/24A61K33/26A61K33/30A23V2002/00
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Quick Facts
Patent No.
US 9,375,451
App. No.
14/444,278
Granted
Jun 28, 2016
Kind
B2
Abstract

A nutritional supplement composition for treating nutritional deficiencies caused by a medical condition in subjects is disclosed. The present application further discloses a method of using a nutritional supplements composition for treating a subject with complications resulting from sickle cell anemia. The method comprises administering to a subject an effective amount of the nutritional supplement.

Claims (29)

1. A method for treating a nutritional deficiency associated with abnormally slow energy metabolism or a high energy requirement, comprising:

orally administering to a subject in need of such treatment a daily nutritional supplement having total calories of about 700-980 kcal, wherein about 10-20% of the total calories are derived from protein, about 25-40% of the total calories are derived from fat, and about 45-65% of the total calories are derived from carbohydrate,

wherein the nutritional supplement further comprises arginine, histidine, leucine, valine, cysteine, glutamine, S-allylcysteine, S-allylmercaptocysteine, fructosyl arginine, garlic extract, folic acid and thiocyanate,

wherein the subject does not have sickle cell anemia, and

wherein the nutrition supplement is administered in a ready-to-dispense single-dose form, three-dose form or as a two-pack snack.

2. The method of claim 1 , wherein the subject has an abnormally slow energy metabolism which is related to malnutrition, anorexia, cancer, AIDS or aging.

3. The method of claim 1 , wherein the subject has a high energy requirement related to or resulting from pregnancy, lactation, growth, exercise, infectious disease or recovery from surgical and other injuries.

4. The method of claim 1 , wherein the nutritional supplement is administered orally in the form of a snack.

5. The method of claim 4 , wherein the nutritional supplement is administered orally as the last snack before sleeping.

6. The method of claim 4 , wherein the nutritional supplement is administered as snacks after each meal.

7. The method of claim 1 , wherein the nutritional supplement comprises:

protein in an amount that provides about 14% of the total calories;

fat in an amount that provides about 32% of the total calories; and

carbohydrate that provides about 54% of the total calories.

8. The method of claim 1 , wherein the nutritional supplement comprises about 24-34 grams of protein; about 25-35 grams of fat; and about 96-135 grams of carbohydrate.

9. The method of claim 1 , wherein each amino acid is provided at a per diem dose range of 8-14 mg/kg body weight/day.

10. The method of claim 1 , wherein each amino acid is provided at a per diem dose range of 22-44 mg/kg body weight/day.

11. The method of claim 1 , wherein, wherein the nutritional supplement further comprises one or more antioxidants.

12. The method of claim 11 , wherein, wherein the one or more antioxidants is selected from the group consisting of Vitamin A, Vitamin C, Vitamin E, β-carotene and selenium.

13. The method of claim 11 , wherein the one or more antioxidants comprise Vitamin C and Vitamin E.

14. The method of claim 1 , wherein the nutritional supplement further comprises one or more components selected from the group consisting of: Vitamin A 8,250-250,000 I.U., Vitamin B-1 25-1000 mg, Vitamin B-2 25-1000 mg, Vitamin B-6 25-1000 mg, Vitamin B-12 25-1000 mcg, Vitamin C 25-1000 mg, Vitamin D 100-4000 I.U., Vitamin E 25-1000 I.U., Niacinamide 25-1000 mg, Paraaminobenzoic acid (PABA) 25-1000 mg, Pantothenic Acid 25-1000 mg, Choline Bitartrate 25-1000 mg, Inositol 25-1000 mg, Rutin 8.25-250 mg, Citrus Bioflavonoid Complex 8.25-250 mg, Betaine Hydrochloride 8.25-250 mg, Hesperidin Complex 1.25-50 mg, Folic Acid 100-4000 mcg, Biotin 25-1000 mcg, Calcium 10-400 mg, Iron 8.25-250 mg, Magnesium 5-100 mg, Zinc 5-100 mg, Potassium 3.75-150 mg, Manganese 1.5-60 mg, Iodine 37.5-1500 mcg, Chromium 3.75-150 mcg, and Selenium 2.5-100 mcg.

15. The method of claim 14 , wherein the nutritional supplement further comprises one or more component selected from the group consisting of L-lysine-L-phenylalanine, L-lysine-L-tyrosine, L-histidine-L-lysine-L-tyrosine-L-histidine, and salts thereof at a dose range of 10-150 mg/kg/day.

16. The method of claim 15 , comprising administering to the subject L-lysine-L-phenylalanine or salts thereof at a dose range of 20-80 mg/kg/day.

17. The method of claim 1 , wherein the nutritional supplement comprises thiocyanates in an amount of 100-500 mg.

18. The method of claim 1 , wherein the nutritional supplement comprises thiocyanates mixed with Vitamin B6 at a weight ratio of about 20:1.

19. The method of claim 1 , wherein the nutritional supplement is formulated in a ready-to-dispense single-dose form designed for complete consumption as a snack.

20. The method of claim 1 , wherein the nutritional supplement is formulated in a ready-to-dispense three-dose form designed as a snack after each meal.

21. The method of claim 1 , wherein the nutritional supplement is formulated for complete consumption as a two-pack snack to be taken in the morning and evening.

22. The method of claim 1 , wherein the nutritional supplement is administered in the form of a milk shake, energy drink, infusion, candy bar, cookie or biscuit.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2018
From: NUTRIGLOBAL, INC.
To: MOREHOUSE SCHOOL OF MEDICINE
Reel/Frame 047001/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2014
From: HIBBERT, JACQUELINE M.; STILES, JONATHAN K.; UMEAKUNNE, KAYELLEN; HYACINTH, HYACINTH I.
To: NUTRIGLOBAL, INC.
Reel/Frame 033661/0408 →
Continuity (3)
Continuation 13105383 · May 11, 2011
Provisional Application 61348430 · May 26, 2010
Related Publication 20150017260A1 · Jan 15, 2015