Povidone-iodine topical composition
The present invention relates to a topical pharmaceutical composition comprising povidone-iodine, a tertiary amide, surfactant and coconut oil, useful for killing microbes and treating wounds or sores on the surface of the skin.
1. A method for treating a wound or open sore on a subject which comprises
placing a microbicidal effective amount of a topical pharmaceutical composition onto the wound or open sore and rubbing the composition thereon thoroughly,
said composition comprising:
an antiseptic effective amount of povidone-iodine complex wherein the amount of complexed iodine in the povidone-iodine complex is from about 4% to about 12% by weight of the povidone-iodine complex;
a second component comprising a tertiary amide or a salt thereof or a hydrate thereof, said second component present in an amount from about 0.1% to about 2% by weight of the composition;
coconut oil in an amount from about 0.5% to about 2% by weight of the composition;
an emulsifying effective amount of a surfactant; and
water;
said composition having a pH of about 2.0 to about 3.5 and having a specific gravity from about 0.9 to about 1.1; and
said composition containing less than 5% by weight of an ingredient that reacts with iodine.
2. The method according to claim 1 , wherein the povidone-iodine complex is present in an amount from about 5% to about 10% by weight of the composition.
3. The method according to claim 1 , wherein the surfactant is a polyethylene glycol of 4-(1,1,3,3-tetramethylbutyl)-phenyl, or Nonoxynol 9, or combination thereof.
4. The method according to claim 3 , wherein the povidone-iodine complex is present in an amount from about 5% to about 10% by weight of the composition.
5. The method according to claim 1 , wherein the composition further comprises beeswax.
6. The method according to claim 1 , wherein the tertiary amide has the formula
wherein R 4 is a saturated fatty group of 11-29 carbon atoms;
R 5 and R 6 are independently lower alkyl aryl, aryl lower alkyl, or saturated fatty group containing 11-29 carbon atoms or R 7 :
R 7 is
R 1 —Ar—O—R 2 —O—R 3 —;
R 2 and R 3 are independently alkylene groups containing 1-6 carbon atoms,
R 1 is a lower alkyl, and
Ar is aryl.
7. The method according to claim 6 , wherein R 4 is a saturated fatty group containing 15-21 carbon atoms.
8. The method according to claim 6 , wherein R 5 is aryl or aryl lower alkyl; and R 6 is
R 1 —Ar—O—R 2 —O—R 3 —;
R 2 and R 3 are independently alkylene containing 1-3 carbon atoms; and Ar is aryl.
9. The method according to claim 6 , wherein Ar is phenyl.
10. The method according to claim 6 , wherein R 5 is aryl lower alkyl.
11. The method according to claim 6 , wherein R 5 is benzyl.
12. The method according to claim 11 , wherein R 4 is a saturated fatty group containing 15-21 carbon atoms.
13. The method according to claim 6 , wherein the tertiary amide is benzethonium stearamide or benzalkonium stearamide.
14. The method according to claim 1 , wherein the second component comprises a hydrate of a tertiary amide, wherein the tertiary amide is of the formula
R 4 is a saturated fatty group of 11-29 carbon atoms;
R 5 and R 6 are independently lower alkyl, aryl, aryl lower alkyl, or fatty group containing 11-29 carbon atoms or R 7 ;
R 7 is
R 1 —Ar—O—R 2 —O—R 3 —;
R 2 and R 3 are independently alkylene groups containing 1-6 carbon atoms;
R 1 is an alkyl group containing 1-15 carbon atoms; and
Ar is aryl.
15. The method according to claim 1 , wherein the composition is in the form of a paste, cream or ointment.
16. The method according to claim 1 , wherein the composition is in the form of an aerosol spray.