Methods for treating liver inflammation in a subject suffering from non-alcoholic steatohepatitis
The invention is in the field of prevention and medical treatment of liver diseases, in particular non-alcoholic steatohepatitis (NASH). The invention provides means and methods for the treatment of hepatic inflammation, fibrosis and more in particular NASH. More in particular, the invention provides a composition capable of raising anti-oxLDL antibodies in vivo for use in the treatment of liver inflammation or fibrosis.
1. A method for the treatment of a subject suffering from non-alcoholic steatohepatitis liver inflammation; the method comprising:
administering to the subject a composition that passively or actively immunizes the subject against oxidized low density lipoprotein;
so as to treat the liver inflammation in the subject as may be determined by a decreased level of tumor necrosis factor, interleukin-1beta, interleukin 6, or monocyte chemoattractant protein-1 in the liver of the subject.
2. The method according to claim 1 , wherein the composition passively immunizes the subject against oxidized low density lipoprotein.
3. The method according to claim 2 , wherein the composition comprises antibodies against oxidized low density lipoprotein.
4. The method according to claim 1 , wherein the composition actively immunizes the subject against oxidized low density lipoprotein.
5. The method according to claim 4 , wherein the composition comprises a phosphorylcholine headgroup.
6. The method according to claim 5 , wherein the composition comprises a Streptococcus pneumoniae antigen.
7. The method according to claim 6 , wherein the Streptococcus pneumoniae antigen is derived from heat-inactivated Streptococcus pneumoniae.
8. A method of treating a subject diagnosed as suffering from non-alcoholic steatohepatitis liver inflammation, the method comprising:
delivering anti-oxidized low density lipoprotein antibodies or a phosphorylcholine headgroup to the subject,
so as to treat the subject for liver inflammation as may be determined by a decreased level of tumor necrosis factor, interleukin-1beta, interleukin 6, or monocyte chemoattractant protein-1 in the liver of the subject.
9. The method according to claim 8 , comprising administering a composition comprising a Streptococcus pneumoniae antigen to the subject.
10. The method according to claim 9 , wherein the S. pneumoniae antigen is derived from heat-inactivated S. pneumoniae.
11. A method for the treatment of liver inflammation in a subject suffering from non-alcoholic steatohepatitis; the method comprising:
administering to the subject a composition comprising antibodies against oxidized low density lipoprotein,
so as to treat the liver inflammation in the subject as may be determined by a decreased level of tumor necrosis factor, interleukin-1beta, interleukin 6, or monocyte chemoattractant protein-1 in the liver of the subject.