Imidazo pyridine compounds
The present invention provides compounds of the formula I, wherein X is a bond or CH 2 ; Q is CH 2 or O; L is selected from the group consisting of —OCH 2 — and —CH 2 O—; or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors.
1. A compound of the formula I
wherein X is a bond;
Q is CH 2 or O;
L is selected from the group consisting of —OCH 2 — and —CH 2 O—;
or a pharmaceutically acceptable salt thereof.
2. A compound or salt according to claim 1 wherein Q is O.
3. A compound or salt according to claim 1 wherein Q is CH 2.
4. A compound or salt according to claim 3 wherein L is —OCH 2 —.
5. A compound or salt according to claim 1 which is 5,6-dihydro-8H-imidazo [2,1-c][1,4]oxazin-6-ylmethyl 2-(2,3-dihydro-1H-inden-2-ylamino)-5 ,7-dihydro-6H-pyrrolo [3,4-d]pyrimidine-6-carboxylate:
6. A compound or salt according to claim 1 which is 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ylmethyl 2-(2,3-dihydro-1H-inden-2-ylamino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate:
7. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, according to claim 1 , in combination with one or more pharmaceutically acceptable carriers, diluents, or excipients.
8. A method of treating pain in a patient, comprising administering to a patient in need thereof, an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
9. A method of treating pain associated with osteoarthritis in a patient, comprising administering to a patient in need thereof, an effective amount of a compound according to claim 1 ; or a pharmaceutically acceptable salt thereof.